Entity Details

Primary name PRDM9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQV7
EntryNamePRDM9_HUMAN
FullNameHistone-lysine N-methyltransferase PRDM9
TaxID9606
Evidenceevidence at protein level
Length894
SequenceStatuscomplete
DateCreated2001-11-16
DateModified2021-06-02

Ontological Relatives

GenesPRDM9

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0006311 meiotic gene conversion
GO:0006355 regulation of transcription, DNA-templated
GO:0007129 homologous chromosome pairing at meiosis
GO:0007292 female gamete generation
GO:0010468 regulation of gene expression
GO:0010844 recombination hotspot binding
GO:0010845 positive regulation of reciprocal meiotic recombination
GO:0016584 nucleosome positioning
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044648 histone H3-K4 dimethylation
GO:0046872 metal ion binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0048232 male gamete generation
GO:0051567 histone H3-K9 methylation
GO:0051568 histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:0097198 histone H3-K36 trimethylation
GO:0097676 histone H3-K36 dimethylation
GO:0097692 histone H3-K4 monomethylation
GO:1905437 positive regulation of histone H3-K4 trimethylation
GO:1905516 positive regulation of fertilization
GO:1990918 double-strand break repair involved in meiotic recombination
GO:2001255 positive regulation of histone H3-K36 trimethylation

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001909 Krueppel-associated boxDomainDomain
IPR003655 Krueppel-associated box-relatedDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR019041 SSXRD motifSiteConserved site
IPR036051 KRAB domain superfamilyFamilyHomologous superfamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily
IPR044417 PRDM7/PRDM9, PR/SET domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PRDM9_HUMANPRDM9_HUMANBioGRID26833727 details