Entity Details

Primary name DUOX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NRD8
EntryNameDUOX2_HUMAN
FullNameDual oxidase 2
TaxID9606
Evidenceevidence at protein level
Length1548
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesDUOX2

GO terms

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GOName
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006590 thyroid hormone generation
GO:0006952 defense response
GO:0006979 response to oxidative stress
GO:0009615 response to virus
GO:0009986 cell surface
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0020037 heme binding
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0042335 cuticle development
GO:0042446 hormone biosynthetic process
GO:0042554 superoxide anion generation
GO:0042744 hydrogen peroxide catabolic process
GO:0043020 NADPH oxidase complex
GO:0045177 apical part of cell
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051591 response to cAMP
GO:0070062 extracellular exosome
GO:0090303 positive regulation of wound healing
GO:0106293 NADH oxidase H202-forming activity
GO:0106294 NADPH oxidase H202-forming activity
GO:2000147 positive regulation of cell motility

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013112 FAD-binding 8DomainDomain
IPR013121 Ferric reductase, NAD binding domainDomainDomain
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR034818 Dual oxidase 2FamilyFamily
IPR034821 Dual oxidase, peroxidase domainDomainDomain
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DUOX2_HUMANTXD11_HUMANHPRD, UniProt15561711 details
DUOX2_HUMANDOXA2_HUMANUniProt25761904 details