Entity Details

Primary name CDK12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYV4
EntryNameCDK12_HUMAN
FullNameCyclin-dependent kinase 12
TaxID9606
Evidenceevidence at protein level
Length1490
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesCDK12

GO terms

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GOName
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0002944 cyclin K-CDK12 complex
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0008024 cyclin/CDK positive transcription elongation factor complex
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0008380 RNA splicing
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0030332 cyclin binding
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043405 regulation of MAP kinase activity
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
GO:0070816 phosphorylation of RNA polymerase II C-terminal domain
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000737 negative regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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