Entity Details

Primary name PLK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYY3
EntryNamePLK2_HUMAN
FullNameSerine/threonine-protein kinase PLK2
TaxID9606
Evidenceevidence at protein level
Length685
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesPLK2

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000785 chromatin
GO:0000922 spindle pole
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007052 mitotic spindle organization
GO:0007093 mitotic cell cycle checkpoint signaling
GO:0007265 Ras protein signal transduction
GO:0007613 memory
GO:0010508 positive regulation of autophagy
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0030425 dendrite
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0032486 Rap protein signal transduction
GO:0043008 ATP-dependent protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044877 protein-containing complex binding
GO:0045732 positive regulation of protein catabolic process
GO:0046599 regulation of centriole replication
GO:0048167 regulation of synaptic plasticity
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0061000 negative regulation of dendritic spine development
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000773 negative regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033695 Second polo-box domainDomainDomain
IPR033701 First polo-box domainDomainDomain
IPR036947 POLO box domain superfamilyFamilyHomologous superfamily
IPR042825 PLK2, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule