Entity Details

Primary name E2AK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZJ5
EntryNameE2AK3_HUMAN
FullNameEukaryotic translation initiation factor 2-alpha kinase 3
TaxID9606
Evidenceevidence at protein level
Length1116
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK3

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0002063 chondrocyte development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 ER overload response
GO:0007029 endoplasmic reticulum organization
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0018105 peptidyl-serine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031018 endocrine pancreas development
GO:0031642 negative regulation of myelination
GO:0032057 negative regulation of translational initiation in response to stress
GO:0034198 cellular response to amino acid starvation
GO:0034976 response to endoplasmic reticulum stress
GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051879 Hsp90 protein binding
GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0070417 cellular response to cold
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990737 response to manganese-induced endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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