Entity Details

Primary name MBTP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43462
EntryNameMBTP2_HUMAN
FullNameMembrane-bound transcription factor site-2 protease
TaxID9606
Evidenceevidence at protein level
Length519
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesMBTPS2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0004222 metalloendopeptidase activity
GO:0005737 cytoplasm
GO:0008203 cholesterol metabolic process
GO:0016021 integral component of membrane
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031293 membrane protein intracellular domain proteolysis
GO:0034976 response to endoplasmic reticulum stress
GO:0036500 ATF6-mediated unfolded protein response
GO:0045540 regulation of cholesterol biosynthetic process
GO:0046872 metal ion binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0070977 bone maturation
GO:1905897 regulation of response to endoplasmic reticulum stress
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001193 Membrane-bound transcription factor site-2 proteaseFamilyFamily
IPR008915 Peptidase M50DomainDomain
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MBTP2_HUMANATF6B_HUMANHPRD11163209 details