Entity Details

Primary name MARCO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UEW3
EntryNameMARCO_HUMAN
FullNameMacrophage receptor MARCO
TaxID9606
Evidenceevidence at protein level
Length520
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesMARCO

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001664 G protein-coupled receptor binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004888 transmembrane signaling receptor activity
GO:0005044 scavenger receptor activity
GO:0005581 collagen trimer
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0007166 cell surface receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0030666 endocytic vesicle membrane
GO:0038024 cargo receptor activity
GO:0038187 pattern recognition receptor activity
GO:0043277 apoptotic cell clearance
GO:0045087 innate immune response
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097242 amyloid-beta clearance

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001190 SRCR domainDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat
IPR017448 SRCR-like domainDomainDomain
IPR036772 SRCR-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09536 Titanium dioxideDrugbanksmall molecule
DB11132 Silicon dioxideDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MARCO_HUMANSG3A2_HUMANBioGRID, HPRD12847263 details
MARCO_HUMANSG3A1_HUMANBioGRID, HPRD12847263 details