Entity Details

Primary name SMAD6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43541
EntryNameSMAD6_HUMAN
FullNameMothers against decapentaplegic homolog 6
TaxID9606
Evidenceevidence at protein level
Length496
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSMAD6

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0001657 ureteric bud development
GO:0003148 outflow tract septum morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003281 ventricular septum development
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007352 zygotic specification of dorsal/ventral axis
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010991 negative regulation of SMAD protein complex assembly
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031589 cell-substrate adhesion
GO:0031625 ubiquitin protein ligase binding
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034616 response to laminar fluid shear stress
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035904 aorta development
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045444 fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0046872 metal ion binding
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060976 coronary vasculature development
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070698 type I activin receptor binding
GO:0071144 heteromeric SMAD protein complex
GO:0140416 transcription regulator inhibitor activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
SMAD6_HUMANSMUF2_HUMANBioGRID, HPRD, MINT15221015 15231748 15761153 24850914 details
SMAD6_HUMANSTABP_HUMANBioGRID, HPRD, IntAct11483516 details
SMAD6_HUMANPRKX_HUMANUniProt16491121 details
SMAD6_HUMANMK06_HUMANBioGRID, MINT21900206 details
SMAD6_HUMANKS6A5_HUMANBioGRID, MINT21900206 details
SMAD6_HUMANFKB1A_HUMANbhf-ucl16720724 details
SMAD6_HUMANSMAD6_HUMANbhf-ucl9436979 details
SMAD6_HUMANSMAD1_HUMANbhf-ucl, BioGRID, HPRD11483516 12857866 9256479 9436979 details
SMAD6_HUMANACM5_HUMANBioGRID, MINT28298427 details
SMAD6_HUMANPIAS4_HUMANBioGRID12815042 details
SMAD6_HUMANHXC8_HUMANBioGRID, HPRD10722652 details
SMAD6_HUMANSMAD7_HUMANBioGRID, HPRD26555259 9256479 details
SMAD6_HUMANSMUF1_HUMANBioGRID, HPRD11278251 15221015 17676934 21897371 28847510 29950561 details
SMAD6_HUMANTOB1_HUMANHPRD12782279 details
SMAD6_HUMANRUNX2_HUMANHPRD, IntAct16299379 details
SMAD6_HUMANUBE2O_HUMANBioGRID, MINT23455153 details
SMAD6_HUMANRN165_HUMANDIP23610558 details
SMAD6_HUMANCTBP1_HUMANBioGRID14645520 24850914 details
SMAD6_HUMANRN111_HUMANBioGRID, HPRD14657019 details
SMAD6_HUMANM3K7_HUMANBioGRID, HPRD10748100 11737269 details
SMAD6_HUMANTAB1_HUMANBioGRID, HPRD11737269 details
SMAD6_HUMANSTRAP_HUMANBioGRID, HPRD10757800 details
SMAD6_HUMANYAP1_HUMANBioGRID12118366 details
SMAD6_HUMANSMAD2_HUMANBioGRID9256479 details
SMAD6_HUMANSMAD4_HUMANBioGRID15817471 9256479 details
SMAD6_HUMANNEDD4_HUMANBioGRID15496141 details
SMAD6_HUMANWWP1_HUMANBioGRID15221015 15359284 24850914 details
SMAD6_HUMANZEB1_HUMANBioGRID20514018 details
SMAD6_HUMANT22D1_HUMANBioGRID21791611 details
SMAD6_HUMANSMAD5_HUMANBioGRID12857866 details
SMAD6_HUMANPELI1_HUMANBioGRID16951688 details
SMAD6_HUMANBMR1B_HUMANBioGRID, HPRD11483516 15761153 9436979 details
SMAD6_HUMANTGFR1_HUMANBioGRID, HPRD20663871 9335505 9436979 details
SMAD6_HUMANACTY_HUMANBioGRID9436979 details
SMAD6_HUMANBAMBI_HUMANBioGRID19758997 details
SMAD6_HUMANBMPR2_HUMANBioGRID20663871 details
SMAD6_HUMANACVR1_HUMANBioGRID20663871 23455153 details
SMAD6_HUMANBMR1A_HUMANBioGRID20663871 details
SMAD6_HUMANACV1B_HUMANBioGRID20663871 details
SMAD6_HUMANAVR2B_HUMANBioGRID20663871 details
SMAD6_HUMANMYD88_HUMANBioGRID21897371 details
SMAD6_HUMANUBP11_HUMANBioGRID24850914 details
SMAD6_HUMANUBP15_HUMANBioGRID24850914 details
SMAD6_HUMANBPIA1_HUMANBioGRID24850914 details
SMAD6_HUMANLYSC_HUMANBioGRID24850914 details
SMAD6_HUMANPIGR_HUMANBioGRID24850914 details
SMAD6_HUMANWWP2_HUMANBioGRID24850914 details
SMAD6_HUMANITCH_HUMANBioGRID24850914 details
SMAD6_HUMANNED4L_HUMANBioGRID24850914 details
SMAD6_HUMANNASP_HUMANBioGRID24850914 details
SMAD6_HUMANIMA1_HUMANBioGRID24850914 details
SMAD6_HUMANCTBP2_HUMANBioGRID24850914 details
SMAD6_HUMANPIAS3_HUMANBioGRID29950561 details
SMAD6_HUMANTNAP3_HUMANBioGRID29720226 details