Entity Details

Primary name NPCL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHC9
EntryNameNPCL1_HUMAN
FullNameNPC1-like intracellular cholesterol transporter 1
TaxID9606
Evidenceevidence at protein level
Length1359
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesNPC1L1

GO terms

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GOName
GO:0005886 plasma membrane
GO:0006695 cholesterol biosynthetic process
GO:0014850 response to muscle activity
GO:0016324 apical plasma membrane
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030659 cytoplasmic vesicle membrane
GO:0031267 small GTPase binding
GO:0031489 myosin V binding
GO:0031526 brush border membrane
GO:0042157 lipoprotein metabolic process
GO:0042493 response to drug
GO:0044214 spanning component of plasma membrane
GO:0071501 cellular response to sterol depletion
GO:0098856 intestinal lipid absorption

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cytoplasmic vesicle membrane

Domains

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DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR003392 Protein patched/dispatchedFamilyFamily
IPR032190 Niemann-Pick C1, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB11635 TocofersolanDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink