Entity Details

Primary name SIX4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UIU6
EntryNameSIX4_HUMAN
FullNameHomeobox protein SIX4
TaxID9606
Evidenceevidence at protein level
Length781
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesSIX4

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007519 skeletal muscle tissue development
GO:0008582 regulation of synaptic assembly at neuromuscular junction
GO:0008584 male gonad development
GO:0009653 anatomical structure morphogenesis
GO:0030238 male sex determination
GO:0030910 olfactory placode formation
GO:0032880 regulation of protein localization
GO:0034504 protein localization to nucleus
GO:0042472 inner ear morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043586 tongue development
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046661 male sex differentiation
GO:0048538 thymus development
GO:0048699 generation of neurons
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0051451 myoblast migration
GO:0060037 pharyngeal system development
GO:0061055 myotome development
GO:0061197 fungiform papilla morphogenesis
GO:0061551 trigeminal ganglion development
GO:0072075 metanephric mesenchyme development
GO:0072095 regulation of branch elongation involved in ureteric bud branching
GO:0072107 positive regulation of ureteric bud formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0098528 skeletal muscle fiber differentiation
GO:1902725 negative regulation of satellite cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR031701 Homeobox protein SIX1, N-terminal SD domainDomainDomain

Diseases

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