Entity Details

Primary name NOD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y239
EntryNameNOD1_HUMAN
FullNameNucleotide-binding oligomerization domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length953
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesNOD1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009595 detection of biotic stimulus
GO:0010942 positive regulation of cell death
GO:0016045 detection of bacterium
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042834 peptidoglycan binding
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045335 phagocytic vesicle
GO:0046330 positive regulation of JNK cascade
GO:0046658 anchored component of plasma membrane
GO:0050700 CARD domain binding
GO:0050830 defense response to Gram-positive bacterium
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071225 cellular response to muramyl dipeptide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
NOD1_HUMANRIPK2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10224040 10329646 12459189 16517750 17054981 23300079 29997244 details
NOD1_HUMANNOD1_HUMANBioGRID, HPRD, UniProt10329646 10880512 18186648 23300079 details
NOD1_HUMANGBRB1_HUMANBioGRID, IntAct21988832 details
NOD1_HUMANSOX8_HUMANBioGRID, IntAct21988832 details
NOD1_HUMANXIAP_HUMANBioGRID, DIP19667203 details
NOD1_HUMANCRYA2_HUMANIntAct32814053 details
NOD1_HUMANGFAP_HUMANIntAct32814053 details
NOD1_HUMANGLE1_HUMANIntAct32814053 details
NOD1_HUMANLMNA_HUMANIntAct32814053 details
NOD1_HUMANPAK1_HUMANIntAct32814053 details
NOD1_HUMANKLK6_HUMANIntAct32814053 details
NOD1_HUMANSPRE1_HUMANIntAct32814053 details
NOD1_HUMANHD_HUMANIntAct32814053 details
NOD1_HUMANUBC_HUMANBioGRID23300079 details
NOD1_HUMANRNF34_HUMANBioGRID25012219 details
NOD1_HUMANA16L1_HUMANBioGRID19898471 23300079 details
NOD1_HUMANCASP9_HUMANBioGRID, HPRD, MINT10329646 details
NOD1_HUMANHS90A_HUMANBioGRID, IntAct, MINT16083881 17420470 17435760 25036637 details
NOD1_HUMANHS71A_HUMANMINT16083881 details
NOD1_HUMANHS71B_HUMANMINT16083881 details
NOD1_HUMANMAGD1_HUMANIntAct17353931 details
NOD1_HUMANFKBP5_HUMANIntAct25036637 details
NOD1_HUMANMLF2_HUMANIntAct25036637 details
NOD1_HUMANNUDC3_HUMANIntAct25036637 details
NOD1_HUMANPSMD2_HUMANIntAct25036637 details
NOD1_HUMANFKBPL_HUMANIntAct25036637 details
NOD1_HUMANCDC37_HUMANIntAct25036637 details
NOD1_HUMANCYBP_HUMANIntAct25036637 details
NOD1_HUMANTEBP_HUMANIntAct25036637 details
NOD1_HUMANSGT1_HUMANBioGRID, DIP, HPIDb17420470 17435760 23935490 details
NOD1_HUMANOLFM4_HUMANDIP20534456 details
NOD1_HUMANHSPB8_HUMANDIP31273097 details
NOD1_HUMANNLRC4_HUMANBioGRID15107016 details
NOD1_HUMANCARD6_HUMANBioGRID, HPRD12775719 details
NOD1_HUMANCASP1_HUMANBioGRID, HPRD10329646 12459189 details
NOD1_HUMANCASP2_HUMANBioGRID, HPRD10329646 details
NOD1_HUMANCASP4_HUMANBioGRID, HPRD10329646 details
NOD1_HUMANCASP8_HUMANBioGRID, HPRD10329646 details
NOD1_HUMANCFLAR_HUMANBioGRID10329646 details
NOD1_HUMANCSN6_HUMANBioGRID17337451 details
NOD1_HUMANCSN1_HUMANBioGRID17337451 details
NOD1_HUMANTRAF4_HUMANBioGRID21097508 details
NOD1_HUMANPSA7_HUMANBioGRID23839082 details
NOD1_HUMANNOD2_HUMANBioGRID19898471 details
NOD1_HUMANIRGM_HUMANBioGRID25891078 details
NOD1_HUMANNLRP1_HUMANHPRD11113115 details