Entity Details

Primary name AT8A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2Q0
EntryNameAT8A1_HUMAN
FullNamePhospholipid-transporting ATPase IA
TaxID9606
Evidenceevidence at protein level
Length1164
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesATP8A1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006869 lipid transport
GO:0007612 learning
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0030335 positive regulation of cell migration
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
GO:0034220 ion transmembrane transport
GO:0035577 azurophil granule membrane
GO:0035579 specific granule membrane
GO:0042584 chromaffin granule membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0045332 phospholipid translocation
GO:0055085 transmembrane transport
GO:0061092 positive regulation of phospholipid translocation
GO:0070062 extracellular exosome
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140327 flippase activity
GO:0140331 aminophospholipid translocation
GO:0140346 phosphatidylserine flippase activity
GO:0150104 transport across blood-brain barrier
GO:1990531 phospholipid-translocating ATPase complex

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic granule
Cytoplasmic vesicle
Endoplasmic reticulum
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006539 P-type ATPase, subfamily IVFamilyFamily
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR032630 P-type ATPase, C-terminalDomainDomain
IPR032631 P-type ATPase, N-terminalDomainDomain
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00144 Phosphatidyl serineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AT8A1_HUMANCC50A_HUMANBioGRID, DIP, IntAct, UniProt20947505 20961850 21914794 23269685 31416931 details
AT8A1_HUMANCC50B_HUMANUniProt20961850 details