Entity Details

Primary name MTF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y483
EntryNameMTF2_HUMAN
FullNameMetal-response element-binding transcription factor 2
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMTF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0019827 stem cell population maintenance
GO:0035064 methylated histone binding
GO:0035098 ESC/E(Z) complex
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048863 stem cell differentiation
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002999 Tudor domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR025894 Polycomb-like MTF2 factor 2, C-terminal domainDomainDomain
IPR040477 Lysine-specific demethylase 4, Tudor domainDomainDomain
IPR042014 MTF2, PHD domain 1DomainDomain
IPR042015 MTF2, PHD domain 2DomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
MTF2_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15231748 details
MTF2_HUMANKPCD2_HUMANBioGRID, MINT15231748 details
MTF2_HUMANTMED9_HUMANBioGRID, IntAct21988832 details
MTF2_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
MTF2_HUMANSUV92_HUMANBioGRID, MINT23455924 details
MTF2_HUMANSUV91_HUMANBioGRID, MINT23455924 details
MTF2_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
MTF2_HUMANANM6_HUMANBioGRID, MINT23455924 details
MTF2_HUMANP55G_HUMANBioGRID, IntAct25814554 details
MTF2_HUMANCDN2D_HUMANBioGRID, IntAct32296183 details
MTF2_HUMANGFAP_HUMANIntAct32814053 details
MTF2_HUMANGLE1_HUMANIntAct32814053 details
MTF2_HUMANPRKN_HUMANIntAct32814053 details
MTF2_HUMANDDIT4_HUMANIntAct32814053 details
MTF2_HUMANJPH3_HUMANIntAct32814053 details
MTF2_HUMANSPRE1_HUMANIntAct32814053 details
MTF2_HUMANSYUA_HUMANIntAct32814053 details
MTF2_HUMANATX3_HUMANIntAct32814053 details
MTF2_HUMANTADBP_HUMANIntAct32814053 details
MTF2_HUMANCREB1_HUMANBioGRID, IntAct20211142 details
MTF2_HUMANGASP1_HUMANHPRD16169070 details
MTF2_HUMANVOPP1_HUMANIntAct16169070 details
MTF2_HUMANEZH2_HUMANBioGRID, IntAct, MINT20123894 24457600 24981860 27634302 27705803 details
MTF2_HUMANJARD2_HUMANBioGRID, IntAct20123894 24981860 27705803 details
MTF2_HUMANSUZ12_HUMANBioGRID, IntAct, MINT20123894 24457600 24981860 27705803 28514442 details
MTF2_HUMANFMR1_HUMANIntAct31413325 details
MTF2_HUMANCDC5L_HUMANIntAct31413325 details
MTF2_HUMANBIN1_HUMANIntAct31413325 details
MTF2_HUMANDISC1_HUMANIntAct31413325 details