Entity Details

Primary name SPO11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5K1
EntryNameSPO11_HUMAN
FullNameMeiotic recombination protein SPO11
TaxID9606
Evidenceevidence at protein level
Length396
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSPO11

GO terms

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GOName
GO:0000228 nuclear chromosome
GO:0000706 meiotic DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0001541 ovarian follicle development
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007292 female gamete generation
GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters
GO:0034502 protein localization to chromosome
GO:0042138 meiotic DNA double-strand break formation
GO:0045141 meiotic telomere clustering
GO:0046872 metal ion binding
GO:0048477 oogenesis
GO:1990918 double-strand break repair involved in meiotic recombination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002815 Spo11/DNA topoisomerase VI subunit AFamilyFamily
IPR004084 Meiosis-specific protein Spo11DomainDomain
IPR013048 Meiotic recombination, Spo11FamilyFamily
IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminalDomainDomain
IPR034136 Topoisomerase 6 subunit A/Spo11, TOPRIM domainDomainDomain
IPR036078 Spo11/DNA topoisomerase VI subunit A superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SPO11_HUMANITF2_HUMANBioGRID, IntAct32296183 details