Entity Details

Primary name GSDME_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60443
EntryNameGSDME_HUMAN
FullNameGasdermin-E
TaxID9606
Evidenceevidence at protein level
Length496
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesGSDME

GO terms

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GOName
GO:0002839 positive regulation of immune response to tumor cell
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007605 sensory perception of sound
GO:0008219 cell death
GO:0008285 negative regulation of cell population proliferation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0022829 wide pore channel activity
GO:0043410 positive regulation of MAPK cascade
GO:0060113 inner ear receptor cell differentiation
GO:0070265 necrotic cell death
GO:0070269 pyroptosis
GO:0071356 cellular response to tumor necrosis factor
GO:0098586 cellular response to virus
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:1901612 cardiolipin binding
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR040460 Gasdermin, pore forming domainDomainDomain
IPR041263 Gasdermin, PUB domainDomainDomain
IPR042377 Gasdermin-EFamilyFamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
GSDME_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
GSDME_HUMANITBP1_HUMANBioGRID, IntAct23414517 details
GSDME_HUMANTIFA_HUMANBioGRID, IntAct32296183 details
GSDME_HUMANEGFR_HUMANBioGRID23956138 details