Entity Details

Primary name SHOX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60902
EntryNameSHOX2_HUMAN
FullNameShort stature homeobox protein 2
TaxID9606
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesSHOX2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0002027 regulation of heart rate
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002063 chondrocyte development
GO:0003163 sinoatrial node development
GO:0003170 heart valve development
GO:0003213 cardiac right atrium morphogenesis
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0032330 regulation of chondrocyte differentiation
GO:0035115 embryonic forelimb morphogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0048557 embryonic digestive tract morphogenesis
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0050772 positive regulation of axonogenesis
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060920 cardiac pacemaker cell differentiation
GO:0060931 sinoatrial node cell development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000172 regulation of branching morphogenesis of a nerve

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000047 Helix-turn-helix motifSiteConserved site
IPR001356 Homeobox domainDomainDomain
IPR003654 OAR domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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