Entity Details

Primary name CMC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75746
EntryNameCMC1_HUMAN
FullNameCalcium-binding mitochondrial carrier protein Aralar1
TaxID9606
Evidenceevidence at protein level
Length678
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSLC25A12

GO terms

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GOName
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006094 gluconeogenesis
GO:0006537 glutamate biosynthetic process
GO:0009066 aspartate family amino acid metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015810 aspartate transmembrane transport
GO:0015813 L-glutamate transmembrane transport
GO:0016021 integral component of membrane
GO:0022857 transmembrane transporter activity
GO:0031643 positive regulation of myelination
GO:0042802 identical protein binding
GO:0043490 malate-aspartate shuttle
GO:0051592 response to calcium ion
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR002067 Mitochondrial carrier proteinFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018108 Mitochondrial substrate/solute carrierRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR023395 Mitochondrial carrier domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule

Interactions

4 interactions