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Entity Details
Primary name
IDHC_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
O75874
EntryName
IDHC_HUMAN
FullName
Isocitrate dehydrogenase [NADP] cytoplasmic
TaxID
9606
Evidence
evidence at protein level
Length
414
SequenceStatus
complete
DateCreated
2000-05-30
DateModified
2021-06-02
Ontological Relatives
Genes
IDH1
GO terms
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GO
Name
GO:0000287
magnesium ion binding
GO:0004450
isocitrate dehydrogenase (NADP+) activity
GO:0005576
extracellular region
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005777
peroxisome
GO:0005782
peroxisomal matrix
GO:0005829
cytosol
GO:0006097
glyoxylate cycle
GO:0006099
tricarboxylic acid cycle
GO:0006102
isocitrate metabolic process
GO:0006103
2-oxoglutarate metabolic process
GO:0006739
NADP metabolic process
GO:0006740
NADPH regeneration
GO:0006749
glutathione metabolic process
GO:0006979
response to oxidative stress
GO:0008104
protein localization
GO:0008585
female gonad development
GO:0034774
secretory granule lumen
GO:0042802
identical protein binding
GO:0042803
protein homodimerization activity
GO:0043312
neutrophil degranulation
GO:0045296
cadherin binding
GO:0048545
response to steroid hormone
GO:0050661
NADP binding
GO:0051287
NAD binding
GO:0060696
regulation of phospholipid catabolic process
GO:0070062
extracellular exosome
GO:0071071
regulation of phospholipid biosynthetic process
GO:1904724
tertiary granule lumen
GO:1904813
ficolin-1-rich granule lumen
Subcellular Location
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Subcellular Location
Cytoplasm
Peroxisome
Domains
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Domain
Name
Category
Type
IPR004790
Isocitrate dehydrogenase NADP-dependent
Family
Family
IPR019818
Isocitrate/isopropylmalate dehydrogenase, conserved site
Site
Conserved site
IPR024084
Isopropylmalate dehydrogenase-like domain
Domain
Domain
Diseases
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Drugs
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Drug
Name
Source
Type
DB01727
Isocitric Acid
Drugbank
small molecule
DB03461
Nicotinamide adenine dinucleotide phosphate
Drugbank
small molecule
DB09374
Indocyanine green acid form
Swissprot
small molecule
DB14568
Ivosidenib
Drugbank
small molecule
Interactions
28 interactions
Interactor
Partner
Sources
Publications
Link
IDHC_HUMAN
ZHX1_HUMAN
BioGRID, HPRD, IntAct
16169070
details
IDHC_HUMAN
CE57L_HUMAN
MINT
21516116
details
IDHC_HUMAN
IDHC_HUMAN
BioGRID, DIP, MINT
19935646
21516116
26280302
26436839
details
IDHC_HUMAN
CALR_HUMAN
IntAct
32814053
details
IDHC_HUMAN
SERPH_HUMAN
IntAct
32814053
details
IDHC_HUMAN
ODO2_HUMAN
IntAct
32814053
details
IDHC_HUMAN
PECA1_HUMAN
IntAct
32814053
details
IDHC_HUMAN
KAPCA_HUMAN
IntAct
32814053
details
IDHC_HUMAN
TGFR2_HUMAN
IntAct
32814053
details
IDHC_HUMAN
UBE3A_HUMAN
IntAct
32814053
details
IDHC_HUMAN
NEK7_HUMAN
IntAct
32814053
details
IDHC_HUMAN
CALM1_HUMAN
BioGRID, IntAct
31983428
details
IDHC_HUMAN
PEX5_HUMAN
BioGRID
20178365
details
IDHC_HUMAN
AGGF1_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
DKK3_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
EFC4A_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
F131A_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
FHL2_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
FIGL1_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
LAX1_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
NUP62_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
PRD14_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
TMOD4_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
UBL7_HUMAN
BioGRID
27229929
details
IDHC_HUMAN
CALM2_HUMAN
BioGRID
31983428
details
IDHC_HUMAN
CALM3_HUMAN
BioGRID
31983428
details
IDHC_HUMAN
GLUT4_HUMAN
BioGRID
16396496
details
IDHC_HUMAN
SUMO4_HUMAN
HPRD
16236267
details
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