Entity Details

Primary name PAK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75914
EntryNamePAK3_HUMAN
FullNameSerine/threonine-protein kinase PAK 3
TaxID9606
Evidenceevidence at protein level
Length559
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesPAK3

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007409 axonogenesis
GO:0010763 positive regulation of fibroblast migration
GO:0014069 postsynaptic density
GO:0016358 dendrite development
GO:0017124 SH3 domain binding
GO:0030833 regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0032147 activation of protein kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0046872 metal ion binding
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050808 synapse organization
GO:0050852 T cell receptor signaling pathway
GO:0060997 dendritic spine morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0071407 cellular response to organic cyclic compound
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR035063 p21-activated kinase 3, catalytic domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule