Entity Details

Primary name PDE9A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO76083
EntryNamePDE9A_HUMAN
FullNameHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDE9A

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0019934 cGMP-mediated signaling
GO:0032587 ruffle membrane
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043204 perikaryon
GO:0046068 cGMP metabolic process
GO:0046069 cGMP catabolic process
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048471 perinuclear region of cytoplasm

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Endoplasmic reticulum
Golgi apparatus

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB03597 gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycineDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
PDE9A_HUMANTRI32_HUMANBioGRID, HPRD, IntAct16189514 19060904 25416956 25910212 26871637 31515488 32296183 details
PDE9A_HUMANPHIPL_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
PDE9A_HUMANPDE9A_HUMANBioGRID, HPRD, IntAct16189514 25416956 26871637 details
PDE9A_HUMANKR108_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANNT2NA_HUMANBioGRID, IntAct25416956 31515488 details
PDE9A_HUMANKRA92_HUMANBioGRID, IntAct25416956 details
PDE9A_HUMANKRA42_HUMANBioGRID, IntAct25416956 details
PDE9A_HUMANBAG3_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
PDE9A_HUMANCLK1_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANST1E1_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANLAGE3_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANCRY2_HUMANBioGRID, IntAct25416956 32296183 details
PDE9A_HUMANLSMD1_HUMANBioGRID, IntAct25416956 details
PDE9A_HUMANUTP23_HUMANBioGRID, IntAct25416956 details
PDE9A_HUMANGORS2_HUMANBioGRID, IntAct25416956 29892012 details
PDE9A_HUMANSDCB1_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANWDR5_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANUBD_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANPRP18_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANNFIL3_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANIQCB1_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKR122_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKR109_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKR123_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANKR107_HUMANBioGRID, IntAct32296183 details
PDE9A_HUMANTRPV6_HUMANBioGRID25416956 details
PDE9A_HUMANKR103_HUMANBioGRID25416956 details
PDE9A_HUMANNT2NC_HUMANBioGRID25416956 details
PDE9A_HUMANTFAP4_HUMANBioGRID21516116 details
PDE9A_HUMANKRA13_HUMANBioGRID32296183 details
PDE9A_HUMANRSPRY_HUMANBioGRID, IntAct27173435 unassigned1312 details
PDE9A_HUMANOCC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PDE9A_HUMANNPHP3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PDE9A_HUMANKGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PDE9A_HUMANFXR1_HUMANMINT21653829 details
PDE9A_HUMANFXR2_HUMANMINT21653829 details
PDE9A_HUMANNEUL1_HUMANBioGRID31068605 details
PDE9A_HUMANNEU1B_HUMANBioGRID31068605 details