Entity Details

Primary name MRP6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95255
EntryNameMRP6_HUMAN
FullNameATP-binding cassette sub-family C member 6
TaxID9606
Evidenceevidence at protein level
Length1503
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesABCC6

GO terms

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GOName
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006855 drug transmembrane transport
GO:0007601 visual perception
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015867 ATP transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030504 inorganic diphosphate transmembrane transporter activity
GO:0030643 cellular phosphate ion homeostasis
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0055085 transmembrane transport
GO:0071716 leukotriene transport

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR005292 Multi drug resistance-associated proteinFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030239 ATP-binding cassette sub-family C member 6FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00444 TeniposideDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule

Interactions

6 interactions