Entity Details

Primary name VAPB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95292
EntryNameVAPB_HUMAN
FullNameVesicle-associated membrane protein-associated protein B/C
TaxID9606
Evidenceevidence at protein level
Length243
SequenceStatuscomplete
DateCreated2002-11-01
DateModified2021-06-02

Ontological Relatives

GenesVAPB

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007029 endoplasmic reticulum organization
GO:0008017 microtubule binding
GO:0016021 integral component of membrane
GO:0019048 modulation by virus of host process
GO:0019899 enzyme binding
GO:0030148 sphingolipid biosynthetic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0033149 FFAT motif binding
GO:0036498 IRE1-mediated unfolded protein response
GO:0042803 protein homodimerization activity
GO:0044790 negative regulation by host of viral release from host cell
GO:0044791 positive regulation by host of viral release from host cell
GO:0044828 negative regulation by host of viral genome replication
GO:0044829 positive regulation by host of viral genome replication
GO:0044830 modulation by host of viral RNA genome replication
GO:0045070 positive regulation of viral genome replication
GO:0045296 cadherin binding
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
GO:0061817 endoplasmic reticulum-plasma membrane tethering
GO:0090114 COPII-coated vesicle budding
GO:0090158 endoplasmic reticulum membrane organization

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000535 Major sperm protein (MSP) domainDomainDomain
IPR008962 PapD-like superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016763 Vesicle-associated membrane-protein-associated proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
608627 OMIMAmyotrophic lateral sclerosis 8 (ALS8)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.
182980 OMIMSpinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD)A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset. The disease is caused by variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
VAPB_HUMANMTR1A_HUMANBioGRID, HPRD, IntAct17215244 26514267 details
VAPB_HUMANUBP20_HUMANBioGRID, IntAct19615732 25416956 28514442 31515488 32296183 details
VAPB_HUMANVAPA_HUMANBioGRID, HPIDb, IntAct16227268 19515777 26186194 26496610 28514442 34079125 9920726 details
VAPB_HUMANGPR25_HUMANBioGRID, IntAct25416956 32296183 details
VAPB_HUMANTM252_HUMANIntAct32296183 details
VAPB_HUMANTT39B_HUMANBioGRID, IntAct26186194 28514442 32296183 details
VAPB_HUMANF174A_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANRETR3_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANTM101_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANSCN3B_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANPTGES_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANZBT22_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANRMD2_HUMANBioGRID, IntAct25416956 26186194 28514442 32296183 details
VAPB_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANJAGN1_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANAIG1_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANCYBR1_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANCY561_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANRCAS1_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANRNK_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANEBP_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANZDH15_HUMANBioGRID, IntAct32296183 details
VAPB_HUMANEMD_HUMANBioGRID, IntAct25910212 34079125 details
VAPB_HUMANOSBL2_HUMANBioGRID, IntAct24885147 25416956 26186194 28514442 31515488 details
VAPB_HUMANOSBL1_HUMANBioGRID, IntAct, UniProt26186194 28514442 29858488 details
VAPB_HUMANA4_HUMANUniProt26045787 details
VAPB_HUMANARL16_HUMANIntAct32814053 details
VAPB_HUMANKRA92_HUMANIntAct32814053 details
VAPB_HUMANWDR61_HUMANIntAct32814053 details
VAPB_HUMANSDCB1_HUMANIntAct32814053 details
VAPB_HUMANAP2B1_HUMANIntAct32814053 details
VAPB_HUMANSTX1A_HUMANBioGRID12651853 24885147 details
VAPB_HUMANSTX2_HUMANBioGRID12651853 details
VAPB_HUMANSTX5_HUMANBioGRID12651853 details
VAPB_HUMANSTX4_HUMANBioGRID12651853 34079125 details
VAPB_HUMANSTX1B_HUMANBioGRID12651853 24885147 details
VAPB_HUMANVAMP1_HUMANBioGRID, HPRD9920726 details
VAPB_HUMANVAMP2_HUMANBioGRID, HPRD9920726 details
VAPB_HUMANVKOR1_HUMANBioGRID21103663 details
VAPB_HUMANVHL_HUMANBioGRID22234250 details
VAPB_HUMANFAF1_HUMANBioGRID24885147 26389662 28443643 details
VAPB_HUMANAQP2_HUMANBioGRID28931009 details
VAPB_HUMANGLP1R_HUMANBioGRID28597972 details
VAPB_HUMANKCNB1_HUMANBioGRID29941597 details
VAPB_HUMANRN111_HUMANBioGRID32296183 details
VAPB_HUMANS22A1_HUMANBioGRID31318583 details
VAPB_HUMANZFY27_HUMANUniProt19289470 details
VAPB_HUMANYIF1A_HUMANMINT23736259 details
VAPB_HUMANVAPB_HUMANHPIDb, HPRD16227268 9920726 details
VAPB_HUMANHACD3_HUMANHPIDb18160438 details
VAPB_HUMANSTAR3_HUMANBioGRID, IntAct24105263 26186194 details
VAPB_HUMANSTR3N_HUMANIntAct24105263 details
VAPB_HUMANCCD40_HUMANBioGRID, IntAct27173435 unassigned1312 details
VAPB_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
VAPB_HUMANRBGPR_HUMANBioGRID, IntAct24885147 26186194 28514442 details
VAPB_HUMANRMD3_HUMANBioGRID, IntAct26186194 28514442 30841933 32877691 details
VAPB_HUMANWDR44_HUMANBioGRID, IntAct24885147 26186194 28514442 details
VAPB_HUMANRB3GP_HUMANBioGRID, IntAct24885147 26186194 28514442 details
VAPB_HUMANINSI1_HUMANBioGRID, DIP16606821 details
VAPB_HUMANG3P_HUMANIntAct17540579 details
VAPB_HUMANTERA_HUMANBioGRID24885147 details
VAPB_HUMANGET3_HUMANBioGRID24885147 details
VAPB_HUMANUBC_HUMANBioGRID24885147 details
VAPB_HUMANBAG6_HUMANBioGRID24885147 details
VAPB_HUMANRPN2_HUMANBioGRID24885147 34079125 details
VAPB_HUMANYBOX1_HUMANBioGRID26343856 details
VAPB_HUMANST7_HUMANBioGRID29395067 details