Entity Details

Primary name ABCA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95477
EntryNameABCA1_HUMAN
FullNamePhospholipid-transporting ATPase ABCA1
TaxID9606
Evidenceevidence at protein level
Length2261
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesABCA1

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006869 lipid transport
GO:0007040 lysosome organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008203 cholesterol metabolic process
GO:0008320 protein transmembrane transporter activity
GO:0009306 protein secretion
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015485 cholesterol binding
GO:0016197 endosomal transport
GO:0019222 regulation of metabolic process
GO:0019905 syntaxin binding
GO:0023061 signal release
GO:0030139 endocytic vesicle
GO:0030522 intracellular receptor signaling pathway
GO:0031210 phosphatidylcholine binding
GO:0031267 small GTPase binding
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:0045121 membrane raft
GO:0045332 phospholipid translocation
GO:0045335 phagocytic vesicle
GO:0046623 sphingolipid floppase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051117 ATPase binding
GO:0055091 phospholipid homeostasis
GO:0060155 platelet dense granule organization
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071806 protein transmembrane transport
GO:0090107 regulation of high-density lipoprotein particle assembly
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0097708 intracellular vesicle
GO:0120020 cholesterol transfer activity
GO:0140115 export across plasma membrane
GO:0140328 floppase activity

Subcellular Location

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Subcellular Location
Cell membrane
Endosome

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030365 ATP-binding cassette subfamily A member 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01599 ProbucolDrugbanksmall molecule
DB11635 TocofersolanDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
ABCA1_HUMANSNTB2_HUMANBioGRID, HPRD, IntAct, MINT12054535 16192269 details
ABCA1_HUMANSNTB1_HUMANHPRD, IntAct16192269 16192270 16192292 details
ABCA1_HUMANSNTA1_HUMANHPRD, IntAct14722086 16192269 16192274 details
ABCA1_HUMANDLG3_HUMANHPRD, IntAct16192269 16192271 details
ABCA1_HUMANARHGB_HUMANHPRD, IntAct16192269 16192272 details
ABCA1_HUMANARHGC_HUMANHPRD, IntAct16192269 16192274 details
ABCA1_HUMANMPDZ_HUMANHPRD, IntAct16192269 details
ABCA1_HUMANDLG2_HUMANHPRD, IntAct16192269 16192276 details
ABCA1_HUMANLIN7B_HUMANHPRD, IntAct16192269 16192277 details
ABCA1_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
ABCA1_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
ABCA1_HUMANAPOA1_HUMANbhf-ucl, BioGRID, HPRD, IntAct12084722 27017521 30458687 details
ABCA1_HUMANFADD_HUMANBioGRID, HPRD12235128 details
ABCA1_HUMANUGPA_HUMANBioGRID, HPRD12054535 details
ABCA1_HUMANSDHB_HUMANBioGRID, HPRD12054535 details
ABCA1_HUMANAOXA_HUMANBioGRID, HPRD12054535 details
ABCA1_HUMANPRP8_HUMANBioGRID12054535 details
ABCA1_HUMANCSK22_HUMANBioGRID15218032 details
ABCA1_HUMANLNX1_HUMANBioGRID22889411 details
ABCA1_HUMANATX10_HUMANBioGRID16498633 details
ABCA1_HUMANERBIN_HUMANBioGRID15123239 details
ABCA1_HUMANTRI27_HUMANHPRD12054535 details
ABCA1_HUMANS2534_HUMANHPRD12054535 details
ABCA1_HUMANCDC42_HUMANbhf-ucl, BioGRID16443932 details
ABCA1_HUMANSTX12_HUMANbhf-ucl, BioGRID15469992 details
ABCA1_HUMANFLOT1_HUMANbhf-ucl, BioGRID15469992 details
ABCA1_HUMANABCAC_HUMANbhf-ucl23931754 details
ABCA1_HUMANNR1H2_HUMANbhf-ucl, BioGRID20951680 23931754 25838426 details
ABCA1_HUMANCALX_HUMANDIP25170080 details
ABCA1_HUMANSPTC1_HUMANBioGRID, DIP, HPRD18484747 25170080 details
ABCA1_HUMANDISC1_HUMANIntAct31413325 details
ABCA1_HUMANHGS_HUMANBioGRID21520210 details
ABCA1_HUMANCSN5_HUMANBioGRID19268428 details
ABCA1_HUMANCSN2_HUMANBioGRID19268428 27017521 details
ABCA1_HUMANTF65_HUMANBioGRID25331947 details
ABCA1_HUMANKAPCA_HUMANHPRD12196520 details
ABCA1_HUMANCSK21_HUMANHPRD15218032 details
ABCA1_HUMANPLTP_HUMANHPRD14559902 details
ABCA1_HUMANLIN7C_HUMANHPRD16192275 details
ABCA1_HUMANLIN7A_HUMANHPRD14722086 16192278 details
ABCA1_HUMANSHAN1_HUMANHPRD16192279 details
ABCA1_HUMANDLG5_HUMANHPRD16192281 details
ABCA1_HUMANNHRF3_HUMANHPRD16192282 details
ABCA1_HUMANLIMK1_HUMANHPRD16192283 details
ABCA1_HUMANGOPC_HUMANHPRD16192284 details
ABCA1_HUMANLMO7_HUMANHPRD16192285 details
ABCA1_HUMANPDLI4_HUMANHPRD16192286 details
ABCA1_HUMANTIAM1_HUMANHPRD16192287 details
ABCA1_HUMANRPGF6_HUMANHPRD16192288 details
ABCA1_HUMANRIMS2_HUMANHPRD16192289 details
ABCA1_HUMANPALS2_HUMANHPRD16192290 details
ABCA1_HUMANPDLI3_HUMANHPRD16192291 details