Entity Details

Primary name GSHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00390
EntryNameGSHR_HUMAN
FullNameGlutathione reductase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesGSR

GO terms

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GOName
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006749 glutathione metabolic process
GO:0009055 electron transfer activity
GO:0009897 external side of plasma membrane
GO:0015949 nucleobase-containing small molecule interconversion
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class IFamilyFamily
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainDomainDomain
IPR006322 Glutathione reductase, eukaryote/bacterialFamilyFamily
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active siteSiteActive site
IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamilyFamilyHomologous superfamily
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00262 CarmustineDrugbanksmall molecule
DB01644 3,6-dihydroxy-xanthene-9-propionic acidDrugbanksmall molecule
DB02153 3-sulfino-L-alanineDrugbanksmall molecule
DB02553 Glutathionylspermidine disulfideDrugbanksmall molecule
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-ThiolDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule
DB03867 3-nitro-L-tyrosineDrugbanksmall molecule
DB07393 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINEDrugbanksmall molecule
DB07714 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACIDDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09110 Coenzyme MSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule
DB11135 SeleniumSwissprotsmall molecule
DB11590 ThimerosalDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

6 interactions