Entity Details

Primary name UROK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00749
EntryNameUROK_HUMAN
FullNameUrokinase-type plasminogen activator
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPLAU

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0010469 regulation of signaling receptor activity
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0030335 positive regulation of cell migration
GO:0031639 plasminogen activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035579 specific granule membrane
GO:0042127 regulation of cell population proliferation
GO:0042730 fibrinolysis
GO:0043312 neutrophil degranulation
GO:0061041 regulation of wound healing
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:2000097 regulation of smooth muscle cell-matrix adhesion

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR034814 Urokinase-type plasminogen activatorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00594 AmilorideDrugbanksmall molecule
DB01725 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideDrugbanksmall molecule
DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineDrugbanksmall molecule
DB01977 6-(N-Phenylcarbamyl)-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02287 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB02398 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02473 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02526 CRA_10655Drugbanksmall molecule
DB02551 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02705 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB03046 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-CarboximidamideDrugbanksmall molecule
DB03082 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-NaphthamideDrugbanksmall molecule
DB03127 BenzamidineDrugbanksmall molecule
DB03136 4-Iodobenzo[B]Thiophene-2-CarboxamidineDrugbanksmall molecule
DB03159 CRA_8696Drugbanksmall molecule
DB03476 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-CarboxamidineDrugbanksmall molecule
DB03729 2-Amino-1H-benzimidazol-5-olDrugbanksmall molecule
DB03782 N-(1-adamantyl)-N'-(4-guanidinobenzyl)ureaDrugbanksmall molecule
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule
DB03876 Thieno[2,3-B]Pyridine-2-CarboxamidineDrugbanksmall molecule
DB04059 8-(Pyrimidin-2-Ylamino)Naphthalene-2-CarboximidamideDrugbanksmall molecule
DB04172 [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-AlanineDrugbanksmall molecule
DB05254 FibrinolysinDrugbankbiotech
DB06855 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB06856 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINEDrugbanksmall molecule
DB06857 N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDEDrugbanksmall molecule
DB07076 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDEDrugbanksmall molecule
DB07122 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidineDrugbanksmall molecule
DB07129 (2R)-1-(2,6-dimethylphenoxy)propan-2-amineDrugbanksmall molecule
DB07625 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule
DB07626 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule
DB08072 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDEDrugbanksmall molecule
DB08697 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
UROK_HUMANHEM1_HUMANBioGRID, IntAct21988832 details
UROK_HUMANBTK_HUMANBioGRID, IntAct21988832 details
UROK_HUMANMYC_HUMANBioGRID, IntAct21988832 details
UROK_HUMANPAI1_HUMANBioGRID, HPRD, MINT2161846 22449964 2544876 3090045 9184208 details
UROK_HUMANADA28_HUMANBioGRID, IntAct32296183 details
UROK_HUMANUPAR_HUMANBioGRID, DIP, HPRD, IntAct11501527 16879932 18376415 19017363 24457100 3023326 3031025 details
UROK_HUMANSLUR1_HUMANUniProt25168896 details
UROK_HUMANGDN_HUMANBioGRID, IntAct26186194 28514442 9184208 details
UROK_HUMANA4_HUMANIntAct32814053 details
UROK_HUMANTPA_HUMANBioGRID, HPRD7721771 details
UROK_HUMANIPSP_HUMANBioGRID, HPRD2551064 2752144 9365930 details
UROK_HUMANLRP2_HUMANBioGRID, HPRD8344937 details
UROK_HUMANPAI2_HUMANBioGRID, HPRD2161846 2166055 8388810 details
UROK_HUMANPDGFC_HUMANBioGRID22035541 details
UROK_HUMANSCAM5_HUMANBioGRID21163940 details
UROK_HUMANCEBPG_HUMANBioGRID23661758 details
UROK_HUMANKAT8_HUMANBioGRID24953651 details
UROK_HUMANTX101_HUMANBioGRID19017363 details
UROK_HUMANSPB6_HUMANHPRD7548163 details
UROK_HUMANPLMN_HUMANHPRD2829380 3920216 4226004 details
UROK_HUMANTHRB_HUMANHPRD10996659 8428004 details
UROK_HUMANST14_HUMANHPRD10962009 details
UROK_HUMANCATB_HUMANHPRD1900515 details
UROK_HUMANCATL1_HUMANHPRD1551416 details
UROK_HUMANA2AP_HUMANHPRD134998 details
UROK_HUMANHGF_HUMANHPRD1334458 details
UROK_HUMANNID1_HUMANHPRD1499567 details
UROK_HUMANMPRI_HUMANHPRD9566979 details