Entity Details

Primary name CO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01024
EntryNameCO3_HUMAN
FullNameComplement C3
TaxID9606
Evidenceevidence at protein level
Length1663
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesC3

GO terms

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GOName
GO:0001798 positive regulation of type IIa hypersensitivity
GO:0001934 positive regulation of protein phosphorylation
GO:0001970 positive regulation of activation of membrane attack complex
GO:0004866 endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009617 response to bacterium
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010828 positive regulation of glucose transmembrane transport
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010884 positive regulation of lipid storage
GO:0016322 neuron remodeling
GO:0030449 regulation of complement activation
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035846 oviduct epithelium development
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050776 regulation of immune response
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0097242 amyloid-beta clearance
GO:0097278 complement-dependent cytotoxicity
GO:0150062 complement-mediated synapse pruning
GO:0150064 vertebrate eye-specific patterning
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling
GO:2000427 positive regulation of apoptotic cell clearance

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000020 Anaphylatoxin/fibulinDomainDomain
IPR001134 Netrin domainDomainDomain
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR001840 Anaphylatoxin, complement system domainDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018081 Anaphylatoxin, complement systemFamilyHomologous superfamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR035711 Complement C3-likeFamilyFamily
IPR035815 Complement C3-like, NTR domainDomainDomain
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041425 Complement C3/4/5, macroglobulin domain MG1DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00028 Human immunoglobulin GDrugbankbiotech
DB01593 ZincDrugbanksmall molecule
DB01915 S-HydroxycysteineDrugbanksmall molecule
DB06492 MirococeptDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
CO3_HUMANVSIG4_HUMANHPRD, IntAct16530040 17051150 details
CO3_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
CO3_HUMANMCP_HUMANHPRD, InnateDB, IntAct1717583 18796626 23086448 details
CO3_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
CO3_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
CO3_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
CO3_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
CO3_HUMANKR108_HUMANBioGRID, IntAct32296183 details
CO3_HUMANFBLN4_HUMANBioGRID, IntAct32296183 details
CO3_HUMANFA20C_HUMANIntAct22582013 details
CO3_HUMANCFAB_HUMANBioGRID, DIP, HPRD10610782 11367533 19255449 8648130 details
CO3_HUMANCFAH_HUMANBioGRID, DIP, HPRD, IntAct11367533 21317894 21979047 9291131 9988761 details
CO3_HUMANHMGB1_HUMANBioGRID, UniProt29721183 details
CO3_HUMANPROP_HUMANBioGRID, HPRD, IntAct11513971 24797388 3421908 details
CO3_HUMANCATG_HUMANHPRD, IntAct1861080 24355864 details
CO3_HUMANFHR4_HUMANBioGRID, HPRD, IntAct10622723 20042240 22518841 details
CO3_HUMANCR1_HUMANHPRD, IntAct10382758 18796626 9988761 details
CO3_HUMANCFAI_HUMANBioGRID, HPRD, IntAct1401896 18796626 8648130 9291131 details
CO3_HUMANDMBT1_HUMANIntAct22811680 details
CO3_HUMANFHR5_HUMANBioGRID, HPRD11058592 details
CO3_HUMANFHR3_HUMANBioGRID, HPRD10622723 details
CO3_HUMANITAX_HUMANBioGRID, HPRD4062888 7512600 details
CO3_HUMANCBPN_HUMANBioGRID, HPRD11939578 details
CO3_HUMANCO5_HUMANBioGRID, HPRD11367533 details
CO3_HUMANITB2_HUMANBioGRID4062888 details
CO3_HUMANA16L1_HUMANBioGRID30293775 details
CO3_HUMANHS90A_HUMANBioGRID31273033 details
CO3_HUMANVHL_HUMANIntAct17353931 details
CO3_HUMANASF1B_HUMANIntAct17353931 details
CO3_HUMANTRFE_HUMANBioGRID, IntAct27173435 unassigned1312 details
CO3_HUMANITAM_HUMANBioGRID, HPRD11073102 23134465 4062888 details
CO3_HUMANLRP1_HUMANHPRD10608878 details
CO3_HUMANCR2_HUMANHPRD11684127 1830068 details
CO3_HUMANCO3_HUMANHPRD10622723 details
CO3_HUMANVTDB_HUMANHPRD2824652 details
CO3_HUMANLAMA1_HUMANHPRD3488995 details
CO3_HUMANPAPP1_HUMANHPRD6203109 details
CO3_HUMANABL1_HUMANHPRD4062888 details
CO3_HUMANMASP1_HUMANHPRD9719152 details
CO3_HUMANC3AR_HUMANHPRD11342658 details
CO3_HUMANOLFM4_HUMANHPRD2824652 details
CO3_HUMANCO2_HUMANHPRD3546307 details
CO3_HUMANC5AR2_HUMANHPRD11773063 details