Entity Details

Primary name HMDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04035
EntryNameHMDH_HUMAN
FullName3-hydroxy-3-methylglutaryl-coenzyme A reductase
TaxID9606
Evidenceevidence at protein level
Length888
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesHMGCR

GO terms

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GOName
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006695 cholesterol biosynthetic process
GO:0007399 nervous system development
GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0016021 integral component of membrane
GO:0016126 sterol biosynthetic process
GO:0019216 regulation of lipid metabolic process
GO:0019222 regulation of metabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0050709 negative regulation of protein secretion
GO:0070402 NADPH binding
GO:0120225 coenzyme A binding
GO:1900222 negative regulation of amyloid-beta clearance

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/IIFamilyFamily
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal typeFamilyFamily
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoanFamilyFamily
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamilyFamilyHomologous superfamily
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamilyFamilyHomologous superfamily
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamilyFamilyHomologous superfamily
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved siteSiteConserved site
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00175 PravastatinDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01992 Coenzyme ADrugbanksmall molecule
DB03169 (S)-Hmg-CoaDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB04377 MeglutolDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB05317 TAK-475Drugbanksmall molecule
DB06693 MevastatinDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09270 UbidecarenoneDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule