Entity Details

Primary name PA21B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04054
EntryNamePA21B_HUMAN
FullNamePhospholipase A2
TaxID9606
Evidenceevidence at protein level
Length148
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesPLA2G1B

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002227 innate immune response in mucosa
GO:0002446 neutrophil mediated immunity
GO:0004623 phospholipase A2 activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006633 fatty acid biosynthetic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0016042 lipid catabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019731 antibacterial humoral response
GO:0030141 secretory granule
GO:0030593 neutrophil chemotaxis
GO:0032052 bile acid binding
GO:0032431 activation of phospholipase A2 activity
GO:0032757 positive regulation of interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046324 regulation of glucose import
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0050482 arachidonic acid secretion
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001211 Phospholipase A2FamilyFamily
IPR016090 Phospholipase A2 domainDomainDomain
IPR033112 Phospholipase A2, aspartic acid active siteSiteActive site
IPR033113 Phospholipase A2, histidine active siteSiteActive site
IPR036444 Phospholipase A2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00795 SulfasalazineDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB02210 Hexane-1,6-DiolDrugbanksmall molecule
DB02448 N-Tridecanoic AcidDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB02795 P-Anisic AcidDrugbanksmall molecule
DB02938 Heptanoic acidDrugbanksmall molecule
DB03565 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-PhosphoethanolamineDrugbanksmall molecule
DB03587 PyruvaldehydeDrugbanksmall molecule
DB03633 Lpc-EtherDrugbanksmall molecule
DB04552 Niflumic acidDrugbanksmall molecule
DB07657 PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTERDrugbanksmall molecule
DB07836 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOLDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech

Interactions

5 interactions