Entity Details

Primary name PROC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04070
EntryNamePROC_HUMAN
FullNameVitamin K-dependent protein C
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesPROC

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0006508 proteolysis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050728 negative regulation of inflammatory response
GO:0050819 negative regulation of coagulation
GO:1903142 positive regulation of establishment of endothelial barrier

Subcellular Location

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Subcellular Location
Endoplasmic reticulum
Golgi apparatus
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/ZFamilyFamily
IPR017857 Coagulation factor-like, Gla domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
176860 OMIMThrombophilia due to protein C deficiency, autosomal dominant (THPH3)A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. The disease is caused by variants affecting the gene represented in this entry.
612304 OMIMThrombophilia due to protein C deficiency, autosomal recessive (THPH4)A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB00464 Sodium tetradecyl sulfateDrugbanksmall molecule
DB09131 Cupric ChlorideDrugbanksmall molecule
DB09332 KappadioneDrugbanksmall molecule
DB13149 Protein S humanDrugbankbiotech
DB13192 Antihemophilic factor humanDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14738 Turoctocog alfa pegolDrugbankbiotech