Entity Details

Primary name HLAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04439
EntryNameHLAA_HUMAN
FullNameHLA class I histocompatibility antigen, A alpha chain
TaxID9606
Evidenceevidence at protein level
Length365
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesHLA-A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001913 T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002726 positive regulation of T cell cytokine production
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0016567 protein ubiquitination
GO:0019731 antibacterial humoral response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0062061 TAP complex binding
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2000568 positive regulation of memory T cell activation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02740 3-Indolebutyric AcidDrugbanksmall molecule
DB06226 Nelipepimut-SDrugbankbiotech
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
HLAA_HUMANB2MG_HUMANBioGRID, HPRD, IntAct, MINT11502003 1448153 20831383 20844028 24163410 26439010 27649529 8805302 93026 details
HLAA_HUMANSTAT3_HUMANBioGRID, IntAct21988832 details
HLAA_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
HLAA_HUMANKI3L2_HUMANBioGRID, HPRD, IntAct24018270 8617928 8760804 details
HLAA_HUMANKI2S4_HUMANIntAct24018270 details
HLAA_HUMANCCR9_HUMANBioGRID, MINT28298427 details
HLAA_HUMANBUD31_HUMANBioGRID, MINT28298427 details
HLAA_HUMANMEP1B_HUMANUniProt27180358 details
HLAA_HUMANCD8A_HUMANBioGRID, HPRD10809759 9177355 details
HLAA_HUMANMAGA4_HUMANBioGRID, HPRD11502003 21815906 details
HLAA_HUMANMAGA1_HUMANBioGRID, HPRD8647853 details
HLAA_HUMANBAP31_HUMANBioGRID, HPRD11163199 17056546 19342655 34079125 details
HLAA_HUMANCALR_HUMANBioGRID15383281 details
HLAA_HUMANMEOX2_HUMANBioGRID24722188 details
HLAA_HUMANGPR35_HUMANBioGRID28298427 details
HLAA_HUMANLT4R2_HUMANBioGRID28298427 details
HLAA_HUMANHLAC_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAA_HUMANHYOU1_HUMANIntAct17353931 details
HLAA_HUMANHLAA_HUMANHPRD, IntAct12853576 17353931 8617928 8760804 9531263 details
HLAA_HUMANMIC13_HUMANIntAct17353931 details
HLAA_HUMANHLAB_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAA_HUMANSMC2_HUMANIntAct17353931 26439010 details
HLAA_HUMANHLAG_HUMANBioGRID, IntAct17353931 28514442 details
HLAA_HUMANSSRD_HUMANIntAct17353931 details
HLAA_HUMANAT2A3_HUMANIntAct17353931 details
HLAA_HUMANUGGG2_HUMANIntAct17353931 details
HLAA_HUMANEFHD1_HUMANIntAct17353931 details
HLAA_HUMANPDIA3_HUMANHPRD, MINT17467700 9545232 details
HLAA_HUMANTPSNR_HUMANIntAct24163410 26439010 details
HLAA_HUMANTPSN_HUMANBioGRID, HPRD, IntAct11884415 24163410 26439010 8769474 details
HLAA_HUMANKI3S1_HUMANIntAct27649529 details
HLAA_HUMANLIRB2_HUMANIntAct27649529 details
HLAA_HUMANI12R2_HUMANIntAct28514442 details
HLAA_HUMANCALX_HUMANBioGRID, HPRD, IntAct17467700 29568061 details
HLAA_HUMANKAP0_HUMANBioGRID, HPRD, IntAct31980649 6333425 details
HLAA_HUMANDERL1_HUMANBioGRID, HPRD15215855 21245296 34079125 details
HLAA_HUMANTAP1_HUMANBioGRID11884415 17055437 details
HLAA_HUMANCOPB_HUMANBioGRID11884415 details
HLAA_HUMANCOPG1_HUMANBioGRID11884415 details
HLAA_HUMANSYVN1_HUMANBioGRID21245296 details
HLAA_HUMANUB2J1_HUMANBioGRID21245296 details
HLAA_HUMANPSMD2_HUMANBioGRID21245296 details
HLAA_HUMANTRAM1_HUMANBioGRID19121997 details
HLAA_HUMANS61A1_HUMANBioGRID14644099 details
HLAA_HUMANLMAN1_HUMANBioGRID19342655 34079125 details
HLAA_HUMANTAP2_HUMANBioGRID8805302 details
HLAA_HUMANATM_HUMANBioGRID20064447 details
HLAA_HUMANGNAS3_HUMANBioGRID9914489 details
HLAA_HUMANGNAS2_HUMANBioGRID9914489 details
HLAA_HUMANALEX_HUMANBioGRID9914489 details
HLAA_HUMANGNAS1_HUMANBioGRID9914489 details
HLAA_HUMANBAG6_HUMANBioGRID21636303 details
HLAA_HUMANTERA_HUMANBioGRID20702414 details
HLAA_HUMANTM129_HUMANBioGRID24807418 25030448 details
HLAA_HUMANHERC2_HUMANBioGRID25476789 details
HLAA_HUMANATG5_HUMANBioGRID33024031 details
HLAA_HUMANUBB_HUMANHPRD14722266 details
HLAA_HUMANDEK_HUMANHPRD9684994 details
HLAA_HUMANAPLP2_HUMANHPRD19184004 details
HLAA_HUMANERBB2_HUMANHPRD10593938 details
HLAA_HUMANKPCA_HUMANHPRD2941417 details
HLAA_HUMANSRC_HUMANHPRD6304688 6333425 details