Entity Details

Primary name NTRK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04629
EntryNameNTRK1_HUMAN
FullNameHigh affinity nerve growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length796
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesNTRK1

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005030 neurotrophin receptor activity
GO:0005166 neurotrophin p75 receptor binding
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007568 aging
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010465 nerve growth factor receptor activity
GO:0010623 programmed cell death involved in cell development
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019900 kinase binding
GO:0021553 olfactory nerve development
GO:0030183 B cell differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0031175 neuron projection development
GO:0031667 response to nutrient levels
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038180 nerve growth factor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043121 neurotrophin binding
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048406 nerve growth factor binding
GO:0048485 sympathetic nervous system development
GO:0048666 neuron development
GO:0048678 response to axon injury
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051599 response to hydrostatic pressure
GO:0051602 response to electrical stimulus
GO:0051896 regulation of protein kinase B signaling
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0055038 recycling endosome membrane
GO:0060009 Sertoli cell development
GO:0060385 axonogenesis involved in innervation
GO:0061368 behavioral response to formalin induced pain
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071316 cellular response to nicotine
GO:1990090 cellular response to nerve growth factor stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Early endosome membrane
Late endosome membrane
Recycling endosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040665 Tyrosine kinase receptor A, transmembrane domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00321 AmitriptylineDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB13926 CenegerminDrugbankbiotech
DB14723 LarotrectinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
NTRK1_HUMANPTN1_HUMANBioGRID, HPRD, MINT12237455 details
NTRK1_HUMANPTPRC_HUMANIntAct19167335 details
NTRK1_HUMANPTPRG_HUMANIntAct19167335 details
NTRK1_HUMANPTPRB_HUMANIntAct19167335 details
NTRK1_HUMANPTPRJ_HUMANIntAct19167335 details
NTRK1_HUMANPTPRO_HUMANIntAct19167335 details
NTRK1_HUMANPTN12_HUMANBioGRID, IntAct19167335 25921289 details
NTRK1_HUMANPTN22_HUMANIntAct19167335 details
NTRK1_HUMANP85A_HUMANBioGRID, HPRD, MINT25921289 8226808 8384556 details
NTRK1_HUMANSHC1_HUMANBioGRID, HPRD, MINT10092678 10629055 10708759 12446789 25921289 28213521 29715200 7541035 8155326 8183561 8226808 9856458 details
NTRK1_HUMANPLCG1_HUMANBioGRID, HPRD, MINT10092678 10708759 1400471 1715690 25921289 8384556 9856458 details
NTRK1_HUMANNTRK1_HUMANBioGRID, HPRD, MINT, UniProt10388563 11159935 21187090 25921289 26285778 28197073 31801826 details
NTRK1_HUMANNGF_HUMANbhf-ucl, BioGRID, DIP, HPRD10490030 11729324 11738045 14985763 details
NTRK1_HUMANSORT_HUMANbhf-ucl, BioGRID21102451 25921289 details
NTRK1_HUMANTPTE_HUMANBioGRID, MINT28065597 details
NTRK1_HUMANPTPRR_HUMANBioGRID, MINT25921289 28065597 details
NTRK1_HUMANA4_HUMANUniProt28197073 details
NTRK1_HUMANABL1_HUMANBioGRID, HPRD10679771 10708759 details
NTRK1_HUMANMATK_HUMANBioGRID, HPRD10329710 details
NTRK1_HUMANGRB2_HUMANBioGRID, HPRD10748052 11733534 25921289 details
NTRK1_HUMANNTF3_HUMANBioGRID8621424 details
NTRK1_HUMANSH2B1_HUMANBioGRID, HPRD10708759 9856458 details
NTRK1_HUMANSH2B2_HUMANBioGRID, HPRD25921289 9856458 details
NTRK1_HUMANRHG32_HUMANBioGRID, HPRD12446789 25921289 details
NTRK1_HUMANFRS2_HUMANBioGRID, HPRD10092678 details
NTRK1_HUMANGIPC1_HUMANBioGRID, HPRD11251075 details
NTRK1_HUMANTRAF6_HUMANBioGRID16246731 18457658 25708205 details
NTRK1_HUMANNEDD4_HUMANBioGRID16701206 19953087 21332718 25921289 27445338 details
NTRK1_HUMANNED4L_HUMANBioGRID, HPRD16701206 19953087 details
NTRK1_HUMANIRS2_HUMANBioGRID, HPRD11147812 25921289 details
NTRK1_HUMANGGA3_HUMANBioGRID26446845 details
NTRK1_HUMANTRAF4_HUMANBioGRID29715200 details
NTRK1_HUMANERBB2_HUMANBioGRID30898150 details
NTRK1_HUMANHIPK2_HUMANBioGRID18378044 details
NTRK1_HUMANRUSC1_HUMANHPRD15024033 details
NTRK1_HUMANDNJA3_HUMANHPRD15753086 details
NTRK1_HUMANIRS1_HUMANHPRD11147812 details
NTRK1_HUMANSHC2_HUMANHPRD12006576 9507002 details
NTRK1_HUMANPTN6_HUMANBioGRID, MINT15557341 29715200 details
NTRK1_HUMANPHLA3_HUMANIntAct17353931 details
NTRK1_HUMANCBL_HUMANBioGRID, MINT21570973 25921289 details
NTRK1_HUMANHS90B_HUMANBioGRID, IntAct22939624 25921289 details
NTRK1_HUMANULK1_HUMANDIP17389358 details
NTRK1_HUMANSQSTM_HUMANBioGRID, DIP, HPRD10747026 11244088 12471037 17389358 18174161 18457658 25708205 details
NTRK1_HUMANCAV1_HUMANBioGRID, HPRD9867838 details
NTRK1_HUMANRAP1A_HUMANBioGRID, HPRD11466412 details
NTRK1_HUMANSHC3_HUMANBioGRID, HPRD25921289 9507002 details
NTRK1_HUMANRGS19_HUMANBioGRID11251075 details
NTRK1_HUMANHS90A_HUMANBioGRID20663926 22939624 25921289 details
NTRK1_HUMANHSP74_HUMANBioGRID20663926 25921289 details
NTRK1_HUMANCDC37_HUMANBioGRID20663926 25921289 details
NTRK1_HUMANSGSM3_HUMANBioGRID17267689 details
NTRK1_HUMANSRBS1_HUMANBioGRID17548467 details
NTRK1_HUMANACK1_HUMANBioGRID23598414 details
NTRK1_HUMANSNX17_HUMANBioGRID23382219 details
NTRK1_HUMANSNX27_HUMANBioGRID23382219 25921289 details
NTRK1_HUMANGARE1_HUMANBioGRID25921289 details
NTRK1_HUMANCBLB_HUMANBioGRID25921289 details
NTRK1_HUMANPTN11_HUMANBioGRID, HPRD25921289 9282923 details
NTRK1_HUMANKDIS_HUMANBioGRID, HPRD11150334 15167895 25921289 details
NTRK1_HUMANRASA1_HUMANBioGRID, HPRD25921289 8384556 details
NTRK1_HUMANTNR16_HUMANBioGRID, HPRD24333329 25708205 9927421 details
NTRK1_HUMANGGA1_HUMANBioGRID26446845 details
NTRK1_HUMANGGA2_HUMANBioGRID26446845 details
NTRK1_HUMANUBP36_HUMANBioGRID27445338 details
NTRK1_HUMANNFIP1_HUMANBioGRID29911254 details
NTRK1_HUMANSOCS2_HUMANBioGRID29881947 details
NTRK1_HUMANSHC4_HUMANBioGRID28213521 details
NTRK1_HUMANEGR1_HUMANBioGRID18378044 details
NTRK1_HUMANPO4F2_HUMANBioGRID18378044 details
NTRK1_HUMANDYL1_HUMANHPRD11157096 details
NTRK1_HUMANFRS3_HUMANHPRD10629055 details
NTRK1_HUMANCRK_HUMANHPRD7509449 7657647 details
NTRK1_HUMANMK03_HUMANHPRD1463607 details
NTRK1_HUMANUBB_HUMANHPRD16701206 details
NTRK1_HUMANRGRF1_HUMANHPRD15513915 details