Entity Details

Primary name IGF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05019
EntryNameIGF1_HUMAN
FullNameInsulin-like growth factor I
TaxID9606
Evidenceevidence at protein level
Length195
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesIGF1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001501 skeletal system development
GO:0001775 cell activation
GO:0002576 platelet degranulation
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007517 muscle organ development
GO:0008083 growth factor activity
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009408 response to heat
GO:0009441 glycolate metabolic process
GO:0010468 regulation of gene expression
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 muscle hypertrophy
GO:0014904 myotube cell development
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016942 insulin-like growth factor binding protein complex
GO:0030166 proteoglycan biosynthetic process
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0032148 activation of protein kinase B activity
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035630 bone mineralization involved in bone maturation
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0040014 regulation of multicellular organism growth
GO:0042060 wound healing
GO:0042104 positive regulation of activated T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042567 insulin-like growth factor ternary complex
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 cellular protein metabolic process
GO:0045445 myoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051450 myoblast proliferation
GO:0060283 negative regulation of oocyte development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070371 ERK1 and ERK2 cascade
GO:0070382 exocytic vesicle
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0150079 negative regulation of neuroinflammatory response
GO:1902430 negative regulation of amyloid-beta formation
GO:1904075 positive regulation of trophectodermal cell proliferation
GO:1904646 cellular response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR016179 Insulin-likeDomainDomain
IPR022341 Insulin-like growth factor IFamilyFamily
IPR022350 Insulin-like growth factorFamilyFamily
IPR022352 Insulin familyFamilyFamily
IPR022353 Insulin, conserved siteSiteConserved site
IPR036438 Insulin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01890 N,N-Bis(3-(D-gluconamido)propyl)deoxycholamideDrugbanksmall molecule
DB02643 N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateDrugbanksmall molecule