Entity Details

Primary name CHLE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06276
EntryNameCHLE_HUMAN
FullNameCholinesterase
TaxID9606
Evidenceevidence at protein level
Length602
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesBCHE

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0003824 catalytic activity
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0005576 extracellular region
GO:0005641 nuclear envelope lumen
GO:0005788 endoplasmic reticulum lumen
GO:0007612 learning
GO:0008285 negative regulation of cell population proliferation
GO:0014016 neuroblast differentiation
GO:0016020 membrane
GO:0019695 choline metabolic process
GO:0019899 enzyme binding
GO:0033265 choline binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043279 response to alkaloid
GO:0050783 cocaine metabolic process
GO:0050805 negative regulation of synaptic transmission
GO:0051384 response to glucocorticoid
GO:0051593 response to folic acid
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000997 CholinesteraseFamilyFamily
IPR002018 Carboxylesterase, type BDomainDomain
IPR014788 Acetylcholinesterase, tetramerisation domainDomainDomain
IPR019819 Carboxylesterase type B, conserved siteSiteConserved site
IPR019826 Carboxylesterase type B, active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00082 PegvisomantDrugbankbiotech
DB00122 CholineDrugbanksmall molecule
DB00178 RamiprilDrugbanksmall molecule
DB00183 PentagastrinDrugbanksmall molecule
DB00202 SuccinylcholineDrugbanksmall molecule
DB00358 MefloquineDrugbanksmall molecule
DB00382 TacrineDrugbanksmall molecule
DB00391 SulpirideDrugbanksmall molecule
DB00392 ProfenamineDrugbanksmall molecule
DB00449 DipivefrinDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00527 CinchocaineDrugbanksmall molecule
DB00545 PyridostigmineDrugbanksmall molecule
DB00585 NizatidineDrugbanksmall molecule
DB00620 TriamcinoloneDrugbanksmall molecule
DB00674 GalantamineDrugbanksmall molecule
DB00677 IsoflurophateDrugbanksmall molecule
DB00711 DiethylcarbamazineDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00733 PralidoximeDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00772 MalathionDrugbanksmall molecule
DB00790 PerindoprilDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00856 ChlorphenesinSwissprotsmall molecule
DB00868 BenzonatateDrugbanksmall molecule
DB00871 TerbutalineDrugbanksmall molecule
DB00888 MechlorethamineSwissprotsmall molecule
DB00892 OxybuprocaineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00941 HexafluroniumDrugbanksmall molecule
DB00944 DemecariumDrugbanksmall molecule
DB00979 CyclopentolateDrugbanksmall molecule
DB00989 RivastigmineDrugbanksmall molecule
DB01010 EdrophoniumDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01057 EchothiophateDrugbanksmall molecule
DB01116 TrimethaphanDrugbanksmall molecule
DB01122 AmbenoniumDrugbanksmall molecule
DB01135 DoxacuriumDrugbanksmall molecule
DB01161 ChloroprocaineDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01226 MivacuriumDrugbanksmall molecule
DB01245 DecamethoniumDrugbanksmall molecule
DB01337 PancuroniumDrugbanksmall molecule
DB01338 PipecuroniumDrugbanksmall molecule
DB01364 EphedrineDrugbanksmall molecule
DB01400 NeostigmineDrugbanksmall molecule
DB01408 BambuterolDrugbanksmall molecule
DB02811 Diethyl phosphonateDrugbanksmall molecule
DB02845 Methylphosphinic AcidDrugbanksmall molecule
DB03568 Butyric AcidDrugbanksmall molecule
DB03672 9-N-Phenylmethylamino-TacrineDrugbanksmall molecule
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB03822 Ethyl dihydrogen phosphateDrugbanksmall molecule
DB03976 PhosphorylisopropaneDrugbanksmall molecule
DB04250 ButyrylthiocholineDrugbanksmall molecule
DB04572 ThiotepaSwissprotsmall molecule
DB04892 PhenserineDrugbanksmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB05386 RegramostimDrugbankbiotech
DB05875 Sar9, Met (O2)11-Substance PSwissprotsmall molecule
DB06692 AprotininDrugbankbiotech
DB06756 Glycine betaineDrugbanksmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB07681 DODECANESULFONATE IONDrugbanksmall molecule
DB07940 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINEDrugbanksmall molecule
DB08200 (1R)-menthyl hexyl phosphonate groupDrugbanksmall molecule
DB08201 (1S)-menthyl hexyl phosphonate groupDrugbanksmall molecule
DB08658 Ethyl hydrogen diethylamidophosphateDrugbanksmall molecule
DB08893 MirabegronDrugbanksmall molecule
DB08897 AclidiniumDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11397 DichlorvosDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule
DB14031 TretamineSwissprotsmall molecule