Entity Details

Primary name MET_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08581
EntryNameMET_HUMAN
FullNameHepatocyte growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length1390
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesMET

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001886 endothelial cell morphogenesis
GO:0001889 liver development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005008 hepatocyte growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017154 semaphorin receptor activity
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031116 positive regulation of microtubule polymerization
GO:0033674 positive regulation of kinase activity
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035635 entry of bacterium into host cell
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050918 positive chemotaxis
GO:0051497 negative regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0061436 establishment of skin barrier
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0071526 semaphorin-plexin signaling pathway
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001627 Sema domainDomainDomain
IPR002165 Plexin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR016244 Tyrosine-protein kinase, HGF/MSP receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR031148 Plexin familyFamilyFamily
IPR036352 Sema domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB06314 SGX-523Drugbanksmall molecule
DB06896 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamideDrugbanksmall molecule
DB06995 N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamideDrugbanksmall molecule
DB06997 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamideDrugbanksmall molecule
DB07369 N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamideDrugbanksmall molecule
DB07969 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenolDrugbanksmall molecule
DB08079 AMG-208Drugbanksmall molecule
DB08791 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDEDrugbanksmall molecule
DB08865 CrizotinibDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12200 TivantinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule

Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
MET_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT11894096 15123609 16397241 18273061 19433454 19450681 21163258 21222362 25241761 details
MET_HUMANRANB9_HUMANBioGRID, HPRD, MINT12147692 details
MET_HUMANPLXB1_HUMANHPRD, IntAct, MINT, Molecular Connections12198496 15184888 22404908 details
MET_HUMANHGF_HUMANBioGRID, DIP, HPRD, IntAct15167892 16537482 1655405 17804794 17981115 1846706 18495663 18593464 19433454 20624990 22897854 28205554 8380735 details
MET_HUMANPTN1_HUMANIntAct, MINT16537444 18579758 22789536 details
MET_HUMANPTN11_HUMANBioGRID, HPRD, IntAct, MINT18579758 24728074 8662733 details
MET_HUMANPTPRC_HUMANIntAct19167335 details
MET_HUMANPTPRK_HUMANIntAct19167335 details
MET_HUMANPTPRG_HUMANIntAct19167335 details
MET_HUMANPTPRJ_HUMANHPRD, IntAct, MINT12370829 12475979 19167335 details
MET_HUMANPTPRO_HUMANBioGRID, IntAct19167335 28330616 details
MET_HUMANPTN3_HUMANIntAct19167335 details
MET_HUMANPTN12_HUMANIntAct19167335 details
MET_HUMANEGFR_HUMANBioGRID, DIP, HPRD, IntAct, Molecular Connections10722725 20624308 21918175 23866081 24189400 24362532 26551075 details
MET_HUMANSRC_HUMANBioGRID, HPRD, IntAct, Molecular Connections20624308 24034250 24728074 9837958 details
MET_HUMANPASK_HUMANMINT21418524 details
MET_HUMANDNJA3_HUMANHPRD, I2D15546961 21242965 details
MET_HUMANPTPRB_HUMANHPRD, MINT16101282 details
MET_HUMANCD44_HUMANBioGRID, IntAct22897854 28205554 details
MET_HUMANRASA1_HUMANBioGRID, IntAct24728074 details
MET_HUMANP85A_HUMANBioGRID, HPRD, IntAct24728074 7513258 details
MET_HUMANSOCS6_HUMANBioGRID, IntAct24728074 details
MET_HUMANSTAP1_HUMANBioGRID, IntAct24728074 details
MET_HUMANP55G_HUMANBioGRID, IntAct24728074 details
MET_HUMANLCK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC4_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH21B_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHD_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2D3_HUMANBioGRID, IntAct24728074 details
MET_HUMANP85B_HUMANBioGRID, IntAct24728074 details
MET_HUMANKSYK_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC1_HUMANBioGRID, HPRD, IntAct24728074 7731718 9660480 details
MET_HUMANYES_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHB_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH22A_HUMANBioGRID, IntAct24728074 details
MET_HUMANSLAP2_HUMANBioGRID, IntAct24728074 details
MET_HUMANVAV3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH21A_HUMANBioGRID, IntAct24728074 details
MET_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct24728074 7513258 8662733 details
MET_HUMANNCK2_HUMANBioGRID, IntAct24728074 details
MET_HUMANNCK1_HUMANBioGRID, IntAct24728074 details
MET_HUMAN3BP2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS5_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS3_HUMANBioGRID, IntAct24728074 details
MET_HUMANLYN_HUMANBioGRID, IntAct24728074 34079125 details
MET_HUMANTEC_HUMANBioGRID, IntAct24728074 details
MET_HUMANBLK_HUMANBioGRID, IntAct24728074 details
MET_HUMANZAP70_HUMANBioGRID, IntAct24728074 details
MET_HUMANTNS2_HUMANBioGRID, IntAct24728074 details
MET_HUMANPLCG2_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS1_HUMANBioGRID, IntAct24728074 details
MET_HUMANFGR_HUMANBioGRID, IntAct24728074 details
MET_HUMANITK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC3_HUMANBioGRID, IntAct24728074 details
MET_HUMANHCK_HUMANBioGRID, IntAct24728074 details
MET_HUMANPTK6_HUMANBioGRID, IntAct24728074 details
MET_HUMANTXK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS2_HUMANBioGRID, IntAct24728074 details
MET_HUMANGRB7_HUMANBioGRID, IntAct24728074 details
MET_HUMANABL2_HUMANBioGRID, IntAct24728074 details
MET_HUMANMATK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS1_HUMANBioGRID, IntAct24728074 25728680 details
MET_HUMANGRB14_HUMANBioGRID, IntAct24728074 details
MET_HUMANHSH2D_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2B1_HUMANBioGRID, IntAct24728074 details
MET_HUMANBTK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHIP2_HUMANBioGRID, HPRD, IntAct15735664 19713535 24728074 details
MET_HUMANVAV2_HUMANBioGRID, IntAct24728074 details
MET_HUMANFES_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS4_HUMANBioGRID, IntAct24728074 details
MET_HUMANCRK_HUMANBioGRID, IntAct24728074 24828152 details
MET_HUMANSH2B3_HUMANBioGRID, IntAct24728074 details
MET_HUMANBCAR3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2B2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSCRIB_HUMANMINT24550280 details
MET_HUMANMET_HUMANBioGRID, DIP, HPRD16537482 1655405 1655790 17192257 20624990 23794705 26285778 details
MET_HUMANMNDA_HUMANIntAct32814053 details
MET_HUMANGRB2_HUMANBioGRID, HPRD, IntAct11063574 11439336 15546961 19433454 21222362 7511210 8662889 9660480 details
MET_HUMANGLMN_HUMANBioGRID, HPRD11571281 details
MET_HUMANRBP10_HUMANBioGRID, HPRD14684163 details
MET_HUMANPGS2_HUMANBioGRID19433454 details
MET_HUMANITB1_HUMANBioGRID28973887 details
MET_HUMANERBB2_HUMANBioGRID30898150 details
MET_HUMANGLIS2_HUMANBioGRID28205554 details
MET_HUMANMP2K5_HUMANBioGRID28205554 details
MET_HUMANCCND2_HUMANBioGRID28205554 details
MET_HUMANEPHA2_HUMANBioGRID28205554 details
MET_HUMANFGFR4_HUMANBioGRID28205554 details
MET_HUMANSTK11_HUMANBioGRID28205554 details
MET_HUMANFZR1_HUMANBioGRID28205554 details
MET_HUMANERD22_HUMANBioGRID28205554 details
MET_HUMANMP2K3_HUMANBioGRID28205554 details
MET_HUMANCDK4_HUMANBioGRID28205554 details
MET_HUMANCDK6_HUMANBioGRID28205554 details
MET_HUMANCDN2B_HUMANBioGRID28205554 details
MET_HUMANLATS2_HUMANBioGRID28205554 details
MET_HUMANTERT_HUMANBioGRID28205554 details
MET_HUMANMYC_HUMANBioGRID28205554 details
MET_HUMANMERL_HUMANBioGRID28205554 details
MET_HUMANRAF1_HUMANBioGRID28205554 details
MET_HUMANRASF1_HUMANBioGRID28205554 details
MET_HUMANP53_HUMANBioGRID28205554 details
MET_HUMANSNAPN_HUMANHPRD15546961 details
MET_HUMANPHS2_HUMANHPRD15546961 details
MET_HUMANVAV_HUMANHPRD15546961 details
MET_HUMANSNX2_HUMANHPRD15546961 details
MET_HUMANDAPK3_HUMANHPRD15546961 details
MET_HUMANSMC1A_HUMANHPRD15546961 details
MET_HUMANSHIP1_HUMANHPRD15735664 details
MET_HUMANMUC20_HUMANHPRD15314156 details
MET_HUMANGAB1_HUMANBioGRID, HPRD, MINT10734310 10871282 10913131 10995442 9242692 details
MET_HUMAN1433Z_HUMANIntAct17353931 details
MET_HUMANPLXB2_HUMANIntAct15184888 details
MET_HUMANPLXB3_HUMANIntAct15184888 details
MET_HUMANVGFR2_HUMANIntAct22789536 details
MET_HUMANCASP3_HUMANBioGRID, HPRD, IntAct15542841 25241761 details
MET_HUMANMUC1_HUMANMolecular Connections22962849 details
MET_HUMANLAP4B_HUMANIntAct25594178 details
MET_HUMANERBB3_HUMANBioGRID, DIP21918175 25326665 details
MET_HUMANLRIG1_HUMANBioGRID, IntAct17178829 24828152 details
MET_HUMANCADH1_HUMANBioGRID11254878 details
MET_HUMANCTNB1_HUMANBioGRID, HPRD11254878 11929826 details
MET_HUMANSH3K1_HUMANBioGRID11894096 details
MET_HUMANSOS1_HUMANBioGRID9660480 details
MET_HUMANSTAT3_HUMANBioGRID, HPRD9440692 details
MET_HUMANGAB2_HUMANBioGRID10871282 details
MET_HUMANSPSB1_HUMANBioGRID, HPRD15713673 details
MET_HUMANSPSB2_HUMANBioGRID15713673 details
MET_HUMANSPSB3_HUMANBioGRID15713673 details
MET_HUMANSPSB4_HUMANBioGRID15713673 details
MET_HUMANCBLC_HUMANBioGRID22888118 details
MET_HUMANCHIP_HUMANBioGRID21325980 details
MET_HUMANHSP74_HUMANBioGRID21325980 details
MET_HUMANHS90A_HUMANBioGRID21325980 26517842 details
MET_HUMANGGA3_HUMANBioGRID21664574 details
MET_HUMANHGS_HUMANBioGRID, HPRD24828152 8380735 details
MET_HUMANHS90B_HUMANBioGRID26517842 details
MET_HUMAN1433S_HUMANBioGRID29880877 details
MET_HUMANITAV_HUMANBioGRID28973887 details
MET_HUMANGSK3B_HUMANBioGRID30711629 details
MET_HUMANCNR1_HUMANHPRD11894096 details
MET_HUMANTNR6_HUMANHPRD15911745 details
MET_HUMANITB4_HUMANHPRD11733063 14602071 details
MET_HUMANSRC8_HUMANHPRD11439336 details
MET_HUMANBAG1_HUMANHPRD8947043 details