Entity Details

Primary name IL6RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08887
EntryNameIL6RA_HUMAN
FullNameInterleukin-6 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length468
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesIL6R

GO terms

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GOName
GO:0002384 hepatic immune response
GO:0002446 neutrophil mediated immunity
GO:0002548 monocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0004896 cytokine receptor activity
GO:0004915 interleukin-6 receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005896 interleukin-6 receptor complex
GO:0006953 acute-phase response
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010573 vascular endothelial growth factor production
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0019955 cytokine binding
GO:0019970 interleukin-11 binding
GO:0019981 interleukin-6 binding
GO:0031018 endocrine pancreas development
GO:0032717 negative regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0034097 response to cytokine
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0045669 positive regulation of osteoblast differentiation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070110 ciliary neurotrophic factor receptor complex
GO:0070119 ciliary neurotrophic factor binding
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072540 T-helper 17 cell lineage commitment
GO:0097191 extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015321 Type I cytokine receptor, cytokine-binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06273 TocilizumabDrugbankbiotech
DB11767 SarilumabDrugbankbiotech
DB15762 SatralizumabDrugbankbiotech