Entity Details

Primary name 5HT1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08908
EntryName5HT1A_HUMAN
FullName5-hydroxytryptamine receptor 1A
TaxID9606
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesHTR1A

GO terms

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GOName
GO:0001662 behavioral fear response
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008284 positive regulation of cell population proliferation
GO:0014062 regulation of serotonin secretion
GO:0019229 regulation of vasoconstriction
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0035640 exploration behavior
GO:0042053 regulation of dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0045202 synapse
GO:0046883 regulation of hormone secretion
GO:0050795 regulation of behavior
GO:0051378 serotonin binding
GO:0090722 receptor-receptor interaction

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000610 5-Hydroxytryptamine 1A receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00216 EletriptanDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00247 MethysergideDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00422 MethylphenidateDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00669 SumatriptanDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00866 AlprenololDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00952 NaratriptanDrugbanksmall molecule
DB00960 PindololDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01359 PenbutololDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01616 AlverineDrugbanksmall molecule
DB01618 MolindoneDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB04829 Lysergic acid diethylamideDrugbanksmall molecule
DB04884 DapoxetineDrugbanksmall molecule
DB04888 BifeprunoxDrugbanksmall molecule
DB04908 FlibanserinDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB04970 LesopitronDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB05339 MN-305Drugbanksmall molecule
DB05509 LI-301Drugbanksmall molecule
DB05562 NaluzotanDrugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06393 XaliprodenDrugbanksmall molecule
DB06446 DotarizineDrugbanksmall molecule
DB06454 SarizotanDrugbanksmall molecule
DB06506 RepinotanDrugbanksmall molecule
DB06538 RobalzotanDrugbanksmall molecule
DB06684 VilazodoneDrugbanksmall molecule
DB08807 BopindololDrugbanksmall molecule
DB08810 CinitaprideDrugbanksmall molecule
DB08815 LurasidoneDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09244 PirlindoleDrugbanksmall molecule
DB09289 TianeptineDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB12061 PardoprunoxDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14010 5-methoxy-N,N-dimethyltryptamineDrugbanksmall molecule
DB14011 NabiximolsDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule
DB15665 SEP-363856Drugbanksmall molecule