Entity Details

Primary name FGF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09038
EntryNameFGF2_HUMAN
FullNameFibroblast growth factor 2
TaxID9606
Evidenceevidence at protein level
Length288
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesFGF2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0005104 fibroblast growth factor receptor binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010764 negative regulation of fibroblast migration
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0019956 chemokine binding
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030214 hyaluronan catabolic process
GO:0030324 lung development
GO:0030334 regulation of cell migration
GO:0030374 nuclear receptor coactivator activity
GO:0032958 inositol phosphate biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0038001 paracrine signaling
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042056 chemoattractant activity
GO:0042060 wound healing
GO:0042660 positive regulation of cell fate specification
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048598 embryonic morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060548 negative regulation of cell death
GO:0060591 chondroblast differentiation
GO:0061045 negative regulation of wound healing
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072089 stem cell proliferation
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090722 receptor-receptor interaction
GO:1902748 positive regulation of lens fiber cell differentiation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905278 positive regulation of epithelial tube formation
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR002209 Fibroblast growth factor familyFamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR028223 Fibroblast growth factor 2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00364 SucralfateDrugbanksmall molecule
DB00686 Pentosan polysulfateDrugbanksmall molecule
DB00877 SirolimusDrugbanksmall molecule
DB01109 HeparinDrugbanksmall molecule
DB03935 1,4-Dideoxy-O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB03959 N,O6-Disulfo-GlucosamineDrugbanksmall molecule
DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
FGF2_HUMANRS19_HUMANBioGRID, HPRD, MINT11716516 details
FGF2_HUMANFGFP1_HUMANBioGRID, HPRD, IntAct11509569 16257968 details
FGF2_HUMANFGFR1_HUMANBioGRID, DIP, HPRD, IntAct10490103 10748122 10950949 11030354 11786412 14505356 14613973 15096041 15548653 16829530 1697263 17086194 1709094 18199118 19627396 19696444 21693575 22539306 23597562 23597563 26267536 7520751 8609172 8692946 8868466 9174056 details
FGF2_HUMANFGFR2_HUMANBioGRID, IntAct, UniProt10830168 11390973 1697263 17981115 18199118 26267536 28514442 9700203 details
FGF2_HUMANPGS2_HUMANmatrixdb24447999 details
FGF2_HUMANPTX3_HUMANBioGRID, HPRD, IntAct16020751 19627396 20363749 22267482 details
FGF2_HUMANFGFR3_HUMANHPRD, IntAct10574949 14613973 details
FGF2_HUMANCSK21_HUMANBioGRID, HPRD12145206 details
FGF2_HUMANCSK22_HUMANBioGRID, HPRD12145206 7735329 details
FGF2_HUMANCSK2B_HUMANBioGRID, HPRD12145206 details
FGF2_HUMANVTNC_HUMANBioGRID, HPRD11796824 details
FGF2_HUMANSDC3_HUMANBioGRID, HPRD16982797 8344959 details
FGF2_HUMANGPC4_HUMANBioGRID, HPRD11066092 details
FGF2_HUMANRL6_HUMANBioGRID, HPRD9826564 details
FGF2_HUMANTSP1_HUMANBioGRID17996481 details
FGF2_HUMANCRYAB_HUMANBioGRID17487982 details
FGF2_HUMANANM1_HUMANBioGRID, HPRD10652299 details
FGF2_HUMANSNTG1_HUMANBioGRID8609172 details
FGF2_HUMANCSPG4_HUMANBioGRID23124902 details
FGF2_HUMANNRP1_HUMANBioGRID, HPRD15695515 30236477 details
FGF2_HUMANCEP57_HUMANHPRD12717444 details
FGF2_HUMANAPI5_HUMANHPRD11075807 details
FGF2_HUMANCASP1_HUMANHPRD, IntAct18329368 details
FGF2_HUMANPGBM_HUMANHPRD, matrixdb11847221 24509440 details
FGF2_HUMANCD44_HUMANBioGRID, HPRD, IntAct28514442 7532176 details
FGF2_HUMANSDC2_HUMANBioGRID, HPRD, IntAct16982797 28514442 details
FGF2_HUMANSDC1_HUMANBioGRID, HPRD, IntAct16982797 19802384 28514442 details
FGF2_HUMANSDC4_HUMANBioGRID16982797 details
FGF2_HUMANGPC3_HUMANBioGRID, HPRD12478660 details
FGF2_HUMANKAPCA_HUMANBioGRID26056081 details
FGF2_HUMANS100B_HUMANBioGRID21693575 details
FGF2_HUMANRAGE_HUMANBioGRID21693575 details
FGF2_HUMANCBP_HUMANBioGRID22539306 details
FGF2_HUMANH33_HUMANBioGRID22539306 details
FGF2_HUMANFGF2_HUMANHPRD9558385 details
FGF2_HUMANKS6A3_HUMANHPRD15879597 details
FGF2_HUMANFGFR4_HUMANHPRD8530375 details
FGF2_HUMANPLF4_HUMANHPRD9558385 details
FGF2_HUMANCXL13_HUMANHPRD11708770 details
FGF2_HUMANFGRL1_HUMANHPRD11418238 details