Entity Details

Primary name F16P1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09467
EntryNameF16P1_HUMAN
FullNameFructose-1,6-bisphosphatase 1
TaxID9606
Evidenceevidence at protein level
Length338
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFBP1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016208 AMP binding
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0035690 cellular response to drug
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042802 identical protein binding
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
GO:0070062 extracellular exosome
GO:0071286 cellular response to magnesium ion

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000146 Fructose-1,6-bisphosphatase class 1FamilyFamily
IPR020548 Fructose-1,6-bisphosphatase, active siteSiteActive site
IPR028343 Fructose-1,6-bisphosphataseFamilyFamily
IPR033391 Fructose-1-6-bisphosphatase class I, N-terminalDomainDomain
IPR044015 Fructose-1-6-bisphosphatase class 1, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB02778 2,5-Anhydroglucitol-1,6-BiphosphateDrugbanksmall molecule
DB02848 {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-MethanolDrugbanksmall molecule
DB04175 Mdl-29951Drugbanksmall molecule
DB04493 Fructose-6-phosphateDrugbanksmall molecule
DB05053 MB-07803Drugbanksmall molecule
DB05518 Managlinat dialanetilDrugbanksmall molecule
DB07270 N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDEDrugbanksmall molecule
DB07312 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDEDrugbanksmall molecule
DB07321 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDEDrugbanksmall molecule
DB08484 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDEDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
F16P1_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
F16P1_HUMANF16P1_HUMANBioGRID, HPRD, IntAct, MINT16169070 16189514 21516116 2164670 25416956 25502805 25910212 31515488 32296183 details
F16P1_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct16169070 32041737 details
F16P1_HUMANATPK_HUMANBioGRID, HPRD, IntAct16169070 details
F16P1_HUMANPCX4_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANFXR2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
F16P1_HUMANRN183_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANLNX1_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANBIN1_HUMANBioGRID, HPRD, IntAct16275660 details
F16P1_HUMANNKG2C_HUMANBioGRID, IntAct21988832 details
F16P1_HUMANARLY_HUMANBioGRID, IntAct21988832 details
F16P1_HUMANB2CL1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANKC1E_HUMANBioGRID, MINT21900206 details
F16P1_HUMANDC1I1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANHDAC6_HUMANBioGRID, MINT21900206 details
F16P1_HUMANFAK1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANAPC_HUMANBioGRID, MINT24412244 details
F16P1_HUMANAXIN2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBRAF_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
F16P1_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
F16P1_HUMANDCC_HUMANBioGRID, MINT24412244 details
F16P1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
F16P1_HUMANFLCN_HUMANBioGRID, MINT24412244 details
F16P1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
F16P1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
F16P1_HUMANRB_HUMANBioGRID, MINT24412244 details
F16P1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
F16P1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANF16P2_HUMANBioGRID, IntAct25416956 25910212 26186194 28514442 31515488 32041737 32296183 details
F16P1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
F16P1_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
F16P1_HUMANHIF1A_HUMANDIP25043030 details
F16P1_HUMANEPAS1_HUMANDIP25043030 details
F16P1_HUMANBAAT_HUMANIntAct31515488 details
F16P1_HUMANHD_HUMANIntAct32814053 details
F16P1_HUMANPRKN_HUMANBioGRID21209200 details
F16P1_HUMANTIF1B_HUMANBioGRID28394358 30201002 details
F16P1_HUMANTF65_HUMANBioGRID32041737 32754266 details
F16P1_HUMANNOTC1_HUMANBioGRID32041737 details
F16P1_HUMANPIM2_HUMANBioGRID32754266 details
F16P1_HUMANACTN3_HUMANMINT12507293 details
F16P1_HUMANEZH2_HUMANBioGRID31948940 details
F16P1_HUMANACTN1_HUMANHPRD12507293 details