Entity Details

Primary name FURIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09958
EntryNameFURIN_HUMAN
FullNameFurin
TaxID9606
Evidenceevidence at protein level
Length794
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFURIN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001825 blastocyst formation
GO:0002020 protease binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006465 signal peptide processing
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008233 peptidase activity
GO:0009966 regulation of signal transduction
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019058 viral life cycle
GO:0019082 viral protein processing
GO:0022617 extracellular matrix disassembly
GO:0030140 trans-Golgi network transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031638 zymogen activation
GO:0032374 regulation of cholesterol transport
GO:0032455 nerve growth factor processing
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 nerve growth factor production
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032940 secretion by cell
GO:0042176 regulation of protein catabolic process
GO:0042277 peptide binding
GO:0043043 peptide biosynthetic process
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048406 nerve growth factor binding
GO:0051004 regulation of lipoprotein lipase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0090472 dibasic protein processing
GO:0097341 zymogen inhibition
GO:1901394 positive regulation of transforming growth factor beta1 activation
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane
Golgi apparatus
Secreted

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR002884 P domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR022398 Peptidase S8, subtilisin, His-active siteSiteActive site
IPR023827 Peptidase S8, subtilisin, Asp-active siteSiteActive site
IPR023828 Peptidase S8, subtilisin, Ser-active siteSiteActive site
IPR032815 Peptidase S8, pro-domainDomainDomain
IPR034182 Kexin/furin catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR038466 Peptidase S8, pro-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03600 Capric acidDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
FURIN_HUMANMMP14_HUMANBioGRID, IntAct, MINT20608975 21152186 8804434 details
FURIN_HUMANRON_HUMANMolecular Connections21114864 details
FURIN_HUMANMRP6_HUMANBioGRID, IntAct21988832 details
FURIN_HUMANGDF8_HUMANMINT23829672 25543063 details
FURIN_HUMANA4_HUMANIntAct32814053 details
FURIN_HUMANSPB8_HUMANBioGRID, HPRD9442015 details
FURIN_HUMANAP2M1_HUMANBioGRID, HPRD10593987 details
FURIN_HUMANPACS1_HUMANBioGRID, HPRD11331585 9695949 details
FURIN_HUMANFLNC_HUMANHPRD9412467 details
FURIN_HUMANDDX56_HUMANIntAct17353931 details
FURIN_HUMANTGON2_HUMANMINT16977309 details
FURIN_HUMANGORS2_HUMANMINT20608975 details
FURIN_HUMANMMP28_HUMANIntAct21152186 details
FURIN_HUMANLRP1_HUMANHPRD2112085 8546712 details
FURIN_HUMANSORC1_HUMANHPRD12482870 details
FURIN_HUMANATS4_HUMANHPRD14744861 details
FURIN_HUMANMCH_HUMANHPRD10037747 details
FURIN_HUMANFURIN_HUMANHPRD11237874 1629222 details
FURIN_HUMANDSG3_HUMANHPRD12586364 details
FURIN_HUMANZP3_HUMANHPRD11804956 details
FURIN_HUMANNOTC1_HUMANHPRD9653148 details
FURIN_HUMANFLNA_HUMANHPRD9412467 details
FURIN_HUMANEDA_HUMANHPRD11416205 details
FURIN_HUMANSORL_HUMANHPRD11294867 details
FURIN_HUMANTNF13_HUMANHPRD11571266 details
FURIN_HUMANCNMD_HUMANHPRD11323410 details
FURIN_HUMANATS1_HUMANHPRD10373500 details
FURIN_HUMANBACE1_HUMANHPRD10887202 details
FURIN_HUMANNAGPA_HUMANHPRD12058031 details
FURIN_HUMANCONA1_HUMANHPRD12644459 details
FURIN_HUMANITM2C_HUMANHPRD15606899 details
FURIN_HUMANZP4_HUMANHPRD11804956 details
FURIN_HUMANPDGFA_HUMANHPRD12670890 details
FURIN_HUMANVWF_HUMANHPRD1571548 details