Entity Details

Primary name CD28_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10747
EntryNameCD28_HUMAN
FullNameT-cell-specific surface glycoprotein CD28
TaxID9606
Evidenceevidence at protein level
Length220
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCD28

GO terms

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GOName
GO:0001772 immunological synapse
GO:0001819 positive regulation of cytokine production
GO:0002020 protease binding
GO:0002863 positive regulation of inflammatory response to antigenic stimulus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015026 coreceptor activity
GO:0019901 protein kinase binding
GO:0031295 T cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045060 negative thymic T cell selection
GO:0045066 regulatory T cell differentiation
GO:0045070 positive regulation of viral genome replication
GO:0045589 regulation of regulatory T cell differentiation
GO:0045727 positive regulation of translation
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0097190 apoptotic signaling pathway
GO:0098636 protein complex involved in cell adhesion

Subcellular Location

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Subcellular Location
Cell surface
Membrane

Domains

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DomainNameCategoryType
IPR008093 T cell antigen CD28FamilyFamily
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040216 Cytotoxic T-lymphocyte protein 4/CD28FamilyFamily

Diseases

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