Entity Details

Primary name CP2A6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11509
EntryNameCP2A6_HUMAN
FullNameCytochrome P450 2A6
TaxID9606
Evidenceevidence at protein level
Length494
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCYP2A6

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008389 coumarin 7-hydroxylase activity
GO:0008392 arachidonic acid epoxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0009804 coumarin metabolic process
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 drug metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042738 exogenous drug catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0046226 coumarin catabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR008067 Cytochrome P450, E-class, group I, CYP2A-likeFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00170 MenadioneDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00216 EletriptanDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00356 ChlorzoxazoneDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00471 MontelukastDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00531 CyclophosphamideDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00553 MethoxsalenSwissprotsmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00690 FlurazepamDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00916 MetronidazoleDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB01006 LetrozoleDrugbanksmall molecule
DB01011 MetyraponeDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01085 PilocarpineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01213 FomepizoleDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01236 SevofluraneDrugbanksmall molecule
DB01274 ArformoterolDrugbanksmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01544 FlunitrazepamDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04665 CoumarinDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB04977 PlitidepsinSwissprotsmall molecule
DB05676 ApremilastDrugbanksmall molecule
DB06119 CenobamateSwissprotsmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06470 ClomethiazoleDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB06739 SeratrodastDrugbanksmall molecule
DB07609 N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDrugbanksmall molecule
DB07617 N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDrugbanksmall molecule
DB07621 (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDrugbanksmall molecule
DB07623 4,4'-DIPYRIDYL DISULFIDEDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09256 TegafurDrugbanksmall molecule
DB09274 ArtesunateDrugbanksmall molecule
DB09327 Tegafur-uracilDrugbanksmall molecule
DB11586 AsunaprevirDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CP2A6_HUMANNCPR_HUMANBioGRID15680923 details
CP2A6_HUMANCYB5_HUMANBioGRID15680923 details