Entity Details

Primary name CP19A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11511
EntryNameCP19A_HUMAN
FullNameAromatase
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesCYP19A1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0006710 androgen catabolic process
GO:0008585 female gonad development
GO:0009055 electron transfer activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0032355 response to estradiol
GO:0070330 aromatase activity
GO:2000866 positive regulation of estradiol secretion

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00184 NicotineDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00269 ChlorotrianiseneDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00357 AminoglutethimideDrugbanksmall molecule
DB00358 MefloquineDrugbanksmall molecule
DB00389 CarbimazoleDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00856 ChlorphenesinSwissprotsmall molecule
DB00858 DrostanoloneDrugbanksmall molecule
DB00894 TestolactoneDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB00974 Edetic acidSwissprotsmall molecule
DB00990 ExemestaneDrugbanksmall molecule
DB01006 LetrozoleDrugbanksmall molecule
DB01007 TioconazoleDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01127 EconazoleDrugbanksmall molecule
DB01217 AnastrozoleDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01406 DanazolDrugbanksmall molecule
DB02342 2-MethoxyestradiolDrugbanksmall molecule
DB02901 StanoloneDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB04539 GlyphosateDrugbanksmall molecule
DB04794 BifonazoleDrugbanksmall molecule
DB04839 Cyproterone acetateDrugbanksmall molecule
DB05749 MPI-674Drugbanksmall molecule
DB05804 Prasterone sulfateSwissprotsmall molecule
DB05875 Sar9, Met (O2)11-Substance PSwissprotsmall molecule
DB06147 SulfathiazoleDrugbanksmall molecule
DB06423 EndostatinDrugbankbiotech
DB06710 MethyltestosteroneDrugbanksmall molecule
DB06719 BuserelinDrugbankbiotech
DB08804 Nandrolone decanoateDrugbanksmall molecule
DB09389 NorgestrelDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB14598 Edetate calcium disodium anhydrousSwissprotsmall molecule
DB14600 Edetate disodium anhydrousSwissprotsmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CP19A_HUMANCRBN_HUMANBioGRID32219443 details
CP19A_HUMANFANCG_HUMANHPRD11756225 details