Entity Details

Primary name GNS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15586
EntryNameGNS_HUMAN
FullNameN-acetylglucosamine-6-sulfatase
TaxID9606
Evidenceevidence at protein level
Length552
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesGNS

GO terms

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GOName
GO:0005539 glycosaminoglycan binding
GO:0005576 extracellular region
GO:0006027 glycosaminoglycan catabolic process
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0035578 azurophil granule lumen
GO:0042340 keratan sulfate catabolic process
GO:0043202 lysosomal lumen
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR000917 Sulfatase, N-terminalDomainDomain
IPR012251 N-acetylglucosamine-6-sulfataseFamilyFamily
IPR015981 N-acetylglucosamine-6-sulfatase, metazoanFamilyFamily
IPR017850 Alkaline-phosphatase-like, core domain superfamilyFamilyHomologous superfamily
IPR024607 Sulfatase, conserved siteSiteConserved site

Diseases

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