Entity Details

Primary name BPI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17213
EntryNameBPI_HUMAN
FullNameBactericidal permeability-increasing protein
TaxID9606
Evidenceevidence at protein level
Length487
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesBPI

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0019730 antimicrobial humoral response
GO:0019731 antibacterial humoral response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0043031 negative regulation of macrophage activation
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide

Subcellular Location

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Subcellular Location
Cytoplasmic granule membrane
Secreted

Domains

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DomainNameCategoryType
IPR001124 Lipid-binding serum glycoprotein, C-terminalDomainDomain
IPR017942 Lipid-binding serum glycoprotein, N-terminalDomainDomain
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamilyFamilyHomologous superfamily
IPR017954 Lipid-binding serum glycoprotein, conserved siteSiteConserved site
IPR030181 Bactericidal permeability-increasing proteinFamilyFamily
IPR030675 Lipid binding protein BPI/LBPFamilyFamily
IPR032942 BPI/LBP/Plunc familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04178 Di-Stearoyl-3-Sn-PhosphatidylcholineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
BPI_HUMANTRY2_HUMANHPRD11420435 details