Entity Details

Primary name ITA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17301
EntryNameITA2_HUMAN
FullNameIntegrin alpha-2
TaxID9606
Evidenceevidence at protein level
Length1181
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesITGA2

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001618 virus receptor activity
GO:0001666 response to hypoxia
GO:0002687 positive regulation of leukocyte migration
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006929 substrate-dependent cell migration
GO:0006971 hypotonic response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0008283 cell population proliferation
GO:0008305 integrin complex
GO:0009887 animal organ morphogenesis
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010634 positive regulation of epithelial cell migration
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0014075 response to amine
GO:0014850 response to muscle activity
GO:0014911 positive regulation of smooth muscle cell migration
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0031346 positive regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033343 positive regulation of collagen binding
GO:0033591 response to L-ascorbic acid
GO:0033627 cell adhesion mediated by integrin
GO:0034666 integrin alpha2-beta1 complex
GO:0038064 collagen receptor activity
GO:0038065 collagen-activated signaling pathway
GO:0042493 response to drug
GO:0043236 laminin binding
GO:0043388 positive regulation of DNA binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0043589 skin morphogenesis
GO:0043679 axon terminus
GO:0044877 protein-containing complex binding
GO:0045178 basal part of cell
GO:0045184 establishment of protein localization
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045987 positive regulation of smooth muscle contraction
GO:0046872 metal ion binding
GO:0048041 focal adhesion assembly
GO:0048333 mesodermal cell differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050927 positive regulation of positive chemotaxis
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070365 hepatocyte differentiation
GO:0071107 response to parathyroid hormone
GO:0071260 cellular response to mechanical stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0098639 collagen binding involved in cell-matrix adhesion

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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