Entity Details

Primary name PTN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17706
EntryNamePTN2_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 2
TaxID9606
Evidenceevidence at protein level
Length415
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0097677 STAT family protein binding
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum-Golgi intermediate compartment
Nucleus

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
PTN2_HUMANWASL_HUMANIntAct16293614 details
PTN2_HUMANGHR_HUMANBioGRID, HPRD, IntAct12907755 details
PTN2_HUMANTMED9_HUMANBioGRID, UniProt16595549 details
PTN2_HUMANTMEDA_HUMANBioGRID, UniProt16595549 details
PTN2_HUMANITA1_HUMANHPRD, MINT15592458 details
PTN2_HUMANHMGB1_HUMANUniProt31694235 details
PTN2_HUMANSTAT3_HUMANBioGRID, HPRD12359225 15588985 26026268 29386185 31488827 details
PTN2_HUMANSRC_HUMANBioGRID, HPRD15696169 details
PTN2_HUMANSTAT6_HUMANBioGRID17210636 details
PTN2_HUMANOCLN_HUMANBioGRID26090670 details
PTN2_HUMANUBC_HUMANBioGRID28190767 details
PTN2_HUMANEGFR_HUMANBioGRID, HPRD11514572 15588985 9488479 details
PTN2_HUMANSHC1_HUMANBioGRID, HPRD15588985 9488479 details
PTN2_HUMANF220A_HUMANBioGRID26026268 details
PTN2_HUMANIMB1_HUMANBioGRID, HPRD9261175 details
PTN2_HUMANSTX17_HUMANBioGRID23006999 details
PTN2_HUMANCXB1_HUMANBioGRID30401746 details
PTN2_HUMAN1433S_HUMANBioGRID, MINT15778465 details
PTN2_HUMANGOGB1_HUMANUniProt16595549 details
PTN2_HUMANLMAN1_HUMANUniProt16595549 details
PTN2_HUMANINSR_HUMANHPRD, MINT12612081 15192089 15588985 details
PTN2_HUMANSTAT1_HUMANBioGRID, HPRD12138178 12171910 14600148 19171783 details
PTN2_HUMANTRAF2_HUMANBioGRID15696169 details
PTN2_HUMANST7_HUMANBioGRID29395067 details
PTN2_HUMANPGFRB_HUMANHPRD14966296 15588985 details
PTN2_HUMANJAK3_HUMANHPRD11909529 15588985 details
PTN2_HUMANSTA5A_HUMANHPRD11773439 15588985 details
PTN2_HUMANSTA5B_HUMANHPRD11773439 15588985 details
PTN2_HUMANFKBP4_HUMANHPRD15509512 details
PTN2_HUMANCDK1_HUMANHPRD15030318 details
PTN2_HUMANCDK2_HUMANHPRD15030318 details
PTN2_HUMANCDK5_HUMANHPRD15030318 details
PTN2_HUMANJAK1_HUMANHPRD11909529 15588985 details