Entity Details

Primary name S5A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18405
EntryNameS5A1_HUMAN
FullName3-oxo-5-alpha-steroid 4-dehydrogenase 1
TaxID9606
Evidenceevidence at protein level
Length259
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesSRD5A1

GO terms

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GOName
GO:0001655 urogenital system development
GO:0001889 liver development
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006710 androgen catabolic process
GO:0007530 sex determination
GO:0008584 male gonad development
GO:0009055 electron transfer activity
GO:0009267 cellular response to starvation
GO:0014850 response to muscle activity
GO:0016021 integral component of membrane
GO:0016101 diterpenoid metabolic process
GO:0016491 oxidoreductase activity
GO:0021510 spinal cord development
GO:0021766 hippocampus development
GO:0021794 thalamus development
GO:0021854 hypothalamus development
GO:0021983 pituitary gland development
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030539 male genitalia development
GO:0030540 female genitalia development
GO:0032354 response to follicle-stimulating hormone
GO:0032869 cellular response to insulin stimulus
GO:0033218 amide binding
GO:0042428 serotonin metabolic process
GO:0042448 progesterone metabolic process
GO:0042493 response to drug
GO:0042747 circadian sleep/wake cycle, REM sleep
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043627 response to estrogen
GO:0047751 cholestenone 5-alpha-reductase activity
GO:0048471 perinuclear region of cytoplasm
GO:0050213 progesterone 5-alpha-reductase activity
GO:0060348 bone development
GO:0060416 response to growth hormone
GO:0060992 response to fungicide
GO:0070402 NADPH binding
GO:0070852 cell body fiber
GO:0071320 cellular response to cAMP
GO:0071363 cellular response to growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071394 cellular response to testosterone stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071872 cellular response to epinephrine stimulus

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminalDomainDomain
IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenaseFamilyFamily
IPR039357 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00367 LevonorgestrelDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB01126 DutasterideDrugbanksmall molecule
DB01216 FinasterideDrugbanksmall molecule
DB01420 Testosterone propionateDrugbanksmall molecule
DB06412 OxymetholoneDrugbanksmall molecule
DB09389 NorgestrelDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
S5A1_HUMANCCDB1_HUMANIntAct31515488 details