Entity Details

Primary name XRCC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18887
EntryNameXRCC1_HUMAN
FullNameDNA repair protein XRCC1
TaxID9606
Evidenceevidence at protein level
Length633
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesXRCC1

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006288 base-excision repair, DNA ligation
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0010033 response to organic substance
GO:0010836 negative regulation of protein ADP-ribosylation
GO:0019899 enzyme binding
GO:0021587 cerebellum morphogenesis
GO:0021766 hippocampus development
GO:0032356 oxidized DNA binding
GO:0033194 response to hydroperoxide
GO:0042493 response to drug
GO:0050882 voluntary musculoskeletal movement
GO:0061819 telomeric DNA-containing double minutes formation
GO:0070522 ERCC4-ERCC1 complex
GO:1903518 positive regulation of single strand break repair
GO:1904877 positive regulation of DNA ligase activity
GO:1905765 negative regulation of protection from non-homologous end joining at telomere
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR002706 DNA-repair protein Xrcc1, N-terminalDomainDomain
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617633 OMIMSpinocerebellar ataxia, autosomal recessive, 26 (SCAR26)A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
XRCC1_HUMANAPTX_HUMANBioGRID, HPRD, IntAct, MINT15044383 15367657 15380105 15555565 16713569 16964241 26496610 details
XRCC1_HUMANCSK21_HUMANBioGRID, HPRD, MINT15066279 15367657 details
XRCC1_HUMANPNKP_HUMANBioGRID, HPRD, IntAct, MINT11163244 15367657 15385968 17353931 19155274 21637298 26496610 details
XRCC1_HUMANDNLI3_HUMANBioGRID, HPRD, IntAct11163244 11352725 11909950 17353931 20227374 24981860 26496610 29668892 30260704 8264637 9136882 9705932 details
XRCC1_HUMANAPLF_HUMANBioGRID, HPRD, IntAct, MINT17353262 17396150 23178593 26186194 27067600 28514442 details
XRCC1_HUMANDPOLB_HUMANBioGRID, HPRD, IntAct11467963 11909950 15107487 15367657 15520167 25423885 26186194 26496610 28514442 29668892 8978692 details
XRCC1_HUMANFYN_HUMANIntAct17474147 details
XRCC1_HUMANPARP1_HUMANBioGRID, HPRD, IntAct, MINT12897160 14500814 15044383 15555565 18971944 20302655 20303835 24778456 30260704 34079125 9584196 details
XRCC1_HUMANCHK2_HUMANMINT18971944 details
XRCC1_HUMANAPEX1_HUMANBioGRID, HPRD, UniProt11707423 19934257 28986522 details
XRCC1_HUMANRN146_HUMANBioGRID, MINT21799911 21825151 details
XRCC1_HUMANNEIL1_HUMANBioGRID, HPRD15260972 details
XRCC1_HUMANPCNA_HUMANBioGRID, HPRD15107487 20227374 30260704 details
XRCC1_HUMANOGG1_HUMANBioGRID, HPRD12933815 details
XRCC1_HUMANUBC9_HUMANBioGRID15561718 29668892 details
XRCC1_HUMANTOPRS_HUMANBioGRID29668892 details
XRCC1_HUMANFBW1A_HUMANBioGRID31043584 details
XRCC1_HUMANCCNO_HUMANMINT18971944 details
XRCC1_HUMAN3MG_HUMANMINT18971944 details
XRCC1_HUMANDPOLL_HUMANMINT18971944 details
XRCC1_HUMANPOLI_HUMANBioGRID, MINT18923427 details
XRCC1_HUMANH2AX_HUMANMINT19851285 details
XRCC1_HUMANTYDP1_HUMANBioGRID, MINT19851285 24981860 details
XRCC1_HUMANCHD1L_HUMANBioGRID, IntAct19661379 28514442 details
XRCC1_HUMANPARP2_HUMANBioGRID, HPRD11948190 details
XRCC1_HUMANCND3_HUMANBioGRID16543152 details
XRCC1_HUMANRAN_HUMANBioGRID20805321 details
XRCC1_HUMANPOLK_HUMANBioGRID20227374 details
XRCC1_HUMANDPOD1_HUMANBioGRID20227374 details
XRCC1_HUMANPRAF3_HUMANBioGRID19208635 details
XRCC1_HUMANXPO1_HUMANBioGRID21909257 details
XRCC1_HUMANRFA1_HUMANBioGRID24332808 26474068 details
XRCC1_HUMANHS90A_HUMANBioGRID25423885 details
XRCC1_HUMANCTIP_HUMANBioGRID26387952 details
XRCC1_HUMANPRKDC_HUMANBioGRID18678286 details
XRCC1_HUMANCRBN_HUMANBioGRID24292625 details
XRCC1_HUMANXRCC1_HUMANBioGRID9799248 details
XRCC1_HUMANSIR1_HUMANBioGRID31043584 details
XRCC1_HUMANSP100_HUMANBioGRID30260704 details
XRCC1_HUMANPML_HUMANBioGRID30260704 details
XRCC1_HUMANORC5_HUMANBioGRID30260704 details
XRCC1_HUMANSOX2_HUMANBioGRID21280222 details
XRCC1_HUMANBRCA1_HUMANHPRD11352725 details
XRCC1_HUMANCSK22_HUMANHPRD15367657 details