Entity Details

Primary name C11B2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19099
EntryNameC11B2_HUMAN
FullNameCytochrome P450 11B2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesCYP11B2

GO terms

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GOName
GO:0002017 regulation of blood volume by renal aldosterone
GO:0003091 renal water homeostasis
GO:0004507 steroid 11-beta-monooxygenase activity
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0032342 aldosterone biosynthetic process
GO:0032870 cellular response to hormone stimulus
GO:0034650 cortisol metabolic process
GO:0034651 cortisol biosynthetic process
GO:0035865 cellular response to potassium ion
GO:0047783 corticosterone 18-monooxygenase activity
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0071375 cellular response to peptide hormone stimulus

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002399 Cytochrome P450, mitochondrialFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00292 EtomidateDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00700 EplerenoneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB01011 MetyraponeDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04630 AldosteroneDrugbanksmall molecule
DB06281 TorcetrapibDrugbanksmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14545 Hydrocortisone succinateSwissprotsmall molecule

Interactions

4 interactions