Entity Details

Primary name TGM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21980
EntryNameTGM2_HUMAN
FullNameProtein-glutamine gamma-glutamyltransferase 2
TaxID9606
Evidenceevidence at protein level
Length687
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesTGM2

GO terms

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GOName
GO:0000785 chromatin
GO:0001974 blood vessel remodeling
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0008233 peptidase activity
GO:0018149 peptide cross-linking
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0018277 protein deamination
GO:0019904 protein domain specific binding
GO:0031012 extracellular matrix
GO:0031226 intrinsic component of plasma membrane
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 apoptotic cell clearance
GO:0043547 positive regulation of GTPase activity
GO:0045785 positive regulation of cell adhesion
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050568 protein-glutamine glutaminase activity
GO:0050729 positive regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051260 protein homooligomerization
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0060348 bone development
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060662 salivary gland cavitation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071314 cellular response to cocaine
GO:0120295 histone serotonyltransferase activity
GO:0120297 histone dopaminyltransferase activity
GO:0120298 peptide noradrenalinyltransferase activity
GO:0120299 peptide histaminyltransferase activity
GO:1903351 cellular response to dopamine
GO:1904015 cellular response to serotonin
GO:2000425 regulation of apoptotic cell clearance

Subcellular Location

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Subcellular Location
Cell membrane
Chromosome
Cytoplasm
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001102 Transglutaminase, N-terminalDomainDomain
IPR002931 Transglutaminase-likeDomainDomain
IPR008958 Transglutaminase, C-terminalDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013808 Transglutaminase, active siteSiteActive site
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR023608 Protein-glutamine gamma-glutamyltransferase, animalFamilyFamily
IPR036238 Transglutaminase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036985 Transglutaminase-like superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB11254 HexylresorcinolDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
TGM2_HUMANPLCD1_HUMANBioGRID, HPRD, MINT10518533 9512491 details
TGM2_HUMANZ512B_HUMANBioGRID, MINT15231748 details
TGM2_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
TGM2_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15231748 details
TGM2_HUMANAKP13_HUMANIntAct16301118 details
TGM2_HUMANTSP1_HUMANIntAct19542224 details
TGM2_HUMANTAB2_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANABCA1_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANA2MG_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANDSRAD_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANATF4_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANBNIP3_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANCO3_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANCSK22_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANFNTA_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANGLR_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANGRN_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHNRPF_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHPT_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHS71A_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHS71B_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHSP7C_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANTGM2_HUMANBioGRID, HPRD, IntAct10100610 11867708 21988832 details
TGM2_HUMANCERT_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANHNRL1_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANBAT1_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANANR28_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANSRTD1_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANT176A_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANSI1L2_HUMANBioGRID, IntAct21988832 details
TGM2_HUMANPAK1_HUMANBioGRID, MINT21900206 details
TGM2_HUMANVHL_HUMANBioGRID, I2D21625219 details
TGM2_HUMANFINC_HUMANBioGRID, DIP, HPRD, IntAct, matrixdb11278623 11686302 11829448 19738201 20080707 22442151 details
TGM2_HUMANPCOC1_HUMANmatrixdb24117177 details
TGM2_HUMANDYN2_HUMANIntAct32814053 details
TGM2_HUMANTOR1A_HUMANIntAct32814053 details
TGM2_HUMANEF1D_HUMANIntAct32814053 details
TGM2_HUMANFMR1_HUMANIntAct32814053 details
TGM2_HUMANHSPB1_HUMANIntAct32814053 details
TGM2_HUMANPRPS1_HUMANIntAct32814053 details
TGM2_HUMANSYRM_HUMANIntAct32814053 details
TGM2_HUMANRYBP_HUMANIntAct32814053 details
TGM2_HUMANSEPT6_HUMANIntAct32814053 details
TGM2_HUMANSOX14_HUMANIntAct32814053 details
TGM2_HUMANUTP6_HUMANIntAct32814053 details
TGM2_HUMANTTHY_HUMANIntAct32814053 details
TGM2_HUMANWFS1_HUMANIntAct32814053 details
TGM2_HUMANDNM1L_HUMANIntAct32814053 details
TGM2_HUMANKIF1B_HUMANIntAct32814053 details
TGM2_HUMANSPRE1_HUMANIntAct32814053 details
TGM2_HUMANHD_HUMANHPRD, IntAct11442349 32814053 details
TGM2_HUMANHMGB1_HUMANUniProt32867128 details
TGM2_HUMANIMA3_HUMANBioGRID, HPRD10100610 details
TGM2_HUMANA4_HUMANBioGRID21832049 details
TGM2_HUMANPINK1_HUMANBioGRID25557247 details
TGM2_HUMANLACRT_HUMANBioGRID23425695 details
TGM2_HUMANCBL_HUMANBioGRID23770238 details
TGM2_HUMANARNT_HUMANBioGRID23085038 details
TGM2_HUMANPAXI_HUMANBioGRID30120307 details
TGM2_HUMANMMP14_HUMANBioGRID11278623 details
TGM2_HUMANIMA4_HUMANHPRD10100610 details
TGM2_HUMANIKBA_HUMANBioGRID, IntAct16951195 23185316 details
TGM2_HUMANTF65_HUMANBioGRID, HPRD, IntAct16951195 23185316 details
TGM2_HUMANUBC_HUMANMINT19183553 details
TGM2_HUMANNDKA_HUMANMINT19619546 details
TGM2_HUMANPSMD4_HUMANBioGRID, matrixdb19931242 details
TGM2_HUMANK1C19_HUMANDIP20080707 details
TGM2_HUMANSRC_HUMANDIP20080707 details
TGM2_HUMANGSTP1_HUMANBioGRID, HPRD9973324 details
TGM2_HUMANRB_HUMANBioGRID, HPRD9315663 details
TGM2_HUMANH31T_HUMANBioGRID20665636 details
TGM2_HUMANCALM1_HUMANBioGRID14985437 details
TGM2_HUMANCALM2_HUMANBioGRID14985437 details
TGM2_HUMANCALM3_HUMANBioGRID14985437 details
TGM2_HUMANPIAS4_HUMANBioGRID19625650 details
TGM2_HUMANSQSTM_HUMANBioGRID22322858 27031960 details
TGM2_HUMANP53_HUMANBioGRID27031960 details
TGM2_HUMANPA2GA_HUMANBioGRID23913269 details
TGM2_HUMANITB4_HUMANBioGRID27780825 details
TGM2_HUMANGRP75_HUMANBioGRID30590033 details
TGM2_HUMANITB1_HUMANBioGRID11278623 details
TGM2_HUMANITA3_HUMANBioGRID11278623 details
TGM2_HUMANRHOA_HUMANHPRD11350930 details
TGM2_HUMANITB3_HUMANHPRD10684262 details
TGM2_HUMANSPRC_HUMANHPRD7730416 details
TGM2_HUMANTBB2A_HUMANHPRD9973324 details
TGM2_HUMANA2AP_HUMANHPRD10958788 10963790 details
TGM2_HUMANTYB4_HUMANHPRD10611475 details
TGM2_HUMANIF5A1_HUMANHPRD9442029 details
TGM2_HUMANS10A7_HUMANHPRD11258932 details
TGM2_HUMANM3K12_HUMANHPRD10922377 details
TGM2_HUMANCASP3_HUMANHPRD10556977 details
TGM2_HUMANH2B2E_HUMANHPRD9973324 details
TGM2_HUMANPPHLN_HUMANHPRD12853457 details
TGM2_HUMANH2B1C_HUMANHPRD9973324 details
TGM2_HUMANACTB_HUMANHPRD9252372 details
TGM2_HUMANALDOA_HUMANHPRD1353685 details
TGM2_HUMANLTBP1_HUMANHPRD9060478 details
TGM2_HUMANANXA1_HUMANHPRD1670773 details